Calcineurin Regulates Coelomocyte Endocytosis via DYN-1 and CUP-4 in Caenorhabditis elegans
DC Field | Value | Language |
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dc.contributor.author | Song, Hyun-Ok | - |
dc.contributor.author | Lee, Jungsoo | - |
dc.contributor.author | Ji, Yon Ju | - |
dc.contributor.author | Dwivedi, Meenakshi | - |
dc.contributor.author | Cho, Jeong Hoon | - |
dc.contributor.author | Park, Byung-Jae | - |
dc.contributor.author | Ahnn, Joohong | - |
dc.date.accessioned | 2022-12-20T15:50:30Z | - |
dc.date.available | 2022-12-20T15:50:30Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174162 | - |
dc.description.abstract | C. elegans coelomocytes are macrophage-like scavenger cells that provide an excellent in vivo system for the study of clathrin-mediated endocytosis. Using this in vivo system, several genes involved in coelomocyte endocytosis have been identified previously. However, the detailed mechanism of endocytic pathway is still unknown. Here, we report a new function of calcineurin, an evolutionarily conserved Ca2+/calmodulin-dependent Ser/Thr protein phosphatase, in coelomocyte endocytosis. We found that calcineurin mutants show defective coelomocyte endocytosis. Genetic analysis suggests that calcineurin and a GTPase, dynamin (DYN-1), may function upstream of an orphan receptor, CUP-4, to regulate endocytosis. Therefore, we propose a model in which calcineurin may regulate coelomocyte endocytosis via DYN-1 and CUP-4 in C. elegans. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Calcineurin Regulates Coelomocyte Endocytosis via DYN-1 and CUP-4 in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahnn, Joohong | - |
dc.identifier.doi | 10.1007/s10059-010-0116-x | - |
dc.identifier.scopusid | 2-s2.0-78049232699 | - |
dc.identifier.wosid | 000282232200010 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.30, no.3, pp.255 - 262 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 30 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 255 | - |
dc.citation.endPage | 262 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001488344 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | DEPENDENT PROTEIN PHOSPHATASE | - |
dc.subject.keywordPlus | SYNAPTIC VESICLE ENDOCYTOSIS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR NFAT1 | - |
dc.subject.keywordPlus | DYNAMIN-I | - |
dc.subject.keywordPlus | MEDIATED ENDOCYTOSIS | - |
dc.subject.keywordPlus | DEPHOSPHORYLATION | - |
dc.subject.keywordPlus | HOMOLOG | - |
dc.subject.keywordPlus | SHIBIRE | - |
dc.subject.keywordPlus | BINDS | - |
dc.subject.keywordPlus | CDK5 | - |
dc.subject.keywordAuthor | Ca2+ signaling | - |
dc.subject.keywordAuthor | C. elegans | - |
dc.subject.keywordAuthor | endocytosis | - |
dc.subject.keywordAuthor | phosphatase | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10059-010-0116-x | - |
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