Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
DC Field | Value | Language |
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dc.contributor.author | Shen, Nan | - |
dc.contributor.author | Fu, Qiong | - |
dc.contributor.author | Deng, Yun | - |
dc.contributor.author | Qian, Xiaoxia | - |
dc.contributor.author | Zhao, Jian | - |
dc.contributor.author | Kaufman, Kenneth M. | - |
dc.contributor.author | Wu, Yee Ling | - |
dc.contributor.author | Yu, C. Yung | - |
dc.contributor.author | Tang, Yuanjia | - |
dc.contributor.author | Chen, Ji-Yih | - |
dc.contributor.author | Yang, Wanling | - |
dc.contributor.author | Wong, Maida | - |
dc.contributor.author | Kawasaki, Aya | - |
dc.contributor.author | Tsuchiya, Naoyuki | - |
dc.contributor.author | Sumida, Takayuki | - |
dc.contributor.author | Kawaguchi, Yasushi | - |
dc.contributor.author | Howe, Hwee Siew | - |
dc.contributor.author | Mok, Mo Yin | - |
dc.contributor.author | Bang, So-Young | - |
dc.contributor.author | Liu, Fei-Lan | - |
dc.contributor.author | Chang, Deh-Ming | - |
dc.contributor.author | Takasaki, Yoshinari | - |
dc.contributor.author | Hashimoto, Hiroshi | - |
dc.contributor.author | Harley, John B. | - |
dc.contributor.author | Guthridge, Joel M. | - |
dc.contributor.author | Grossman, Jennifer M. | - |
dc.contributor.author | Cantor, Rita M. | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Chen, Shunle | - |
dc.contributor.author | Hahn, Bevra H. | - |
dc.contributor.author | Lau, Yu Lung | - |
dc.contributor.author | Tsao, Betty P. | - |
dc.date.accessioned | 2022-12-20T15:59:52Z | - |
dc.date.available | 2022-12-20T15:59:52Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174217 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a multisystem, autoimmune disease that predominantly affects women. Previous findings that duplicated Toll-like receptor 7 (Tlr7) promotes lupus-like disease in male BXSB mice prompted us to evaluate TLR7 in human SLE. By using a candidate gene approach, we identified and replicated association of a TLR7 3' UTR SNP, rs3853839 (G/C), with SLE in 9,274 Eastern Asians (P(combined) = 6.5 x 10(-10)), with a stronger effect in male than female subjects [ odds ratio, male vs. female = 2.33 (95% CI = 1.64-3.30) vs. 1.24 (95% CI = 1.14-1.34); P = 4.1 x 10(-4)]. G-allele carriers had increased TLR7 transcripts and more pronounced IFN signature than C-allele carriers; heterozygotes had 2.7-fold higher transcripts of G-allele than C-allele. These data established a functional polymorphism in type I IFN pathway gene TLR7 predisposing to SLE, especially in Chinese and Japanese male subjects. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bang, So-Young | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1073/pnas.1001337107 | - |
dc.identifier.scopusid | 2-s2.0-77957673544 | - |
dc.identifier.wosid | 000281637800040 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.107, no.36, pp.15838 - 15843 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 107 | - |
dc.citation.number | 36 | - |
dc.citation.startPage | 15838 | - |
dc.citation.endPage | 15843 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | PLASMACYTOID DENDRITIC CELLS | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | DISEASE-ACTIVITY | - |
dc.subject.keywordPlus | CHROMOSOME INACTIVATION | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASES | - |
dc.subject.keywordPlus | COPY NUMBER | - |
dc.subject.keywordPlus | CAG REPEAT | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordPlus | INTERFERON | - |
dc.subject.keywordAuthor | functional polymorphism | - |
dc.subject.keywordAuthor | disease susceptibility | - |
dc.subject.keywordAuthor | autoimmunity | - |
dc.subject.keywordAuthor | type I interferon | - |
dc.identifier.url | https://www.pnas.org/doi/full/10.1073/pnas.1001337107 | - |
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