Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta
DC Field | Value | Language |
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dc.contributor.author | Jae, Myeong Lee | - |
dc.contributor.author | Jung, Kook Suh | - |
dc.contributor.author | Ji, Seon Jeong | - |
dc.contributor.author | Sang, Yun Cho | - |
dc.contributor.author | Dong, Won Kim | - |
dc.date.accessioned | 2022-12-20T16:09:17Z | - |
dc.date.available | 2022-12-20T16:09:17Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174326 | - |
dc.description.abstract | Background: Reactive oxygen species (ROS) induce lipid peroxidation and tissue damage in the endothelium. We tested the antioxidant effect of lidocaine and procaine on ROS-induced endothelial damage in the rabbit aorta. Methods: Aortic rings isolated from rabbits were suspended in an organ bath filled with Krebs-Henseleit (K-H) solution bubbled with 5% CO2 and 95% O 2 at 37.5°C. After precontraction with phenylephrine (PE, 10 -6 M), changes in tension were recorded following a cumulative administration of acetylcholine (ACh 3 × 10-8 to 10 -6 M). Differences were measured as percentages of ACh-induced relaxation of aortic rings before and after exposure to ROS as generated by electrolysis of the K-H solution. The aortic rings were pretreated with lidocaine or procaine (10-5 M to 3 × 10-3 M) to compare their effects, as well as ROS scavengers, catalase, mannitol, sodium salicylate, and deferoxamine, and a catalase inhibitor, 3-amino-1,2,4-triazole (3AT). Results: Lidocaine and procaine dose-dependently maintained endothelium-dependent relaxation induced by ACh despite ROS activity (P < 0.05 vs control value). The 3AT pretreated procaine (3 × 10-3 M) group decreased more significantly than the un-pretreated procaine group (P < 0.05). Conclusions: These findings suggest that lidocaine and procaine dose-dependently preserve endothelium-dependent vasorelaxation against ROS attack, potentially via hydrogen peroxide scavenging. Copyright © Korean Society of Anesthesiologists, 2010. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한마취통증의학회 | - |
dc.title | Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sang, Yun Cho | - |
dc.contributor.affiliatedAuthor | Dong, Won Kim | - |
dc.identifier.doi | 10.4097/kjae.2010.59.2.104 | - |
dc.identifier.scopusid | 2-s2.0-77956711584 | - |
dc.identifier.bibliographicCitation | Korean Journal of Anesthesiology, v.59, no.2, pp.104 - 110 | - |
dc.relation.isPartOf | Korean Journal of Anesthesiology | - |
dc.citation.title | Korean Journal of Anesthesiology | - |
dc.citation.volume | 59 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 104 | - |
dc.citation.endPage | 110 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001470168 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | acetylcholine | - |
dc.subject.keywordPlus | amitrole | - |
dc.subject.keywordPlus | carbon dioxide | - |
dc.subject.keywordPlus | catalase | - |
dc.subject.keywordPlus | deferoxamine | - |
dc.subject.keywordPlus | lidocaine | - |
dc.subject.keywordPlus | mannitol | - |
dc.subject.keywordPlus | oxygen | - |
dc.subject.keywordPlus | phenylephrine | - |
dc.subject.keywordPlus | procaine | - |
dc.subject.keywordPlus | reactive oxygen metabolite | - |
dc.subject.keywordPlus | salicylate sodium | - |
dc.subject.keywordPlus | abdominal aorta | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | antioxidant activity | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | concentration response | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | electrolysis | - |
dc.subject.keywordPlus | endothelial dysfunction | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | oxidative stress | - |
dc.subject.keywordPlus | rabbit | - |
dc.subject.keywordPlus | vasodilatation | - |
dc.subject.keywordAuthor | 3-amino-1,2,4-triazole | - |
dc.subject.keywordAuthor | Catalase | - |
dc.subject.keywordAuthor | Endothelium | - |
dc.subject.keywordAuthor | Lidocaine | - |
dc.subject.keywordAuthor | Procaine | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.identifier.url | https://ekja.org/journal/view.php?doi=10.4097/kjae.2010.59.2.104 | - |
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