Optimal design and experimental validation of a modified four-zone SMB process for the separation of a ternary amino acid mixture
DC Field | Value | Language |
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dc.contributor.author | Jo, Se-Hee | - |
dc.contributor.author | Nam, Hee-Geun | - |
dc.contributor.author | Mun, Sungyong | - |
dc.date.accessioned | 2022-12-20T16:11:05Z | - |
dc.date.available | 2022-12-20T16:11:05Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 1359-5113 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174343 | - |
dc.description.abstract | For a standard four-zone simulated moving bed (SMB) chromatography, several process modifications have been made in previous studies such that its application scope could be extended to a ternary separation. One of the effective modifications reported was to (1) replace its closed-loop configuration with an open-loop configuration and (2) utilize the extract port for collecting both the intermediate-affinity and the highest-affinity components in regular sequence in every switching period. Most of previous researches on such a modified four-zone SMB (MF-SMB) have been limited to process simulation and optimization. The experimental validation of the MF-SMB process with linear isotherms was attempted in this article for the first time using a ternary amino acid mixture as a model system. First, the intrinsic parameters of three amino acids were estimated from a series of multiple-frontal experiments. The estimated parameter values were then used in the stage of the MF-SMB optimization, which was assisted by an up-to-date genetic algorithm. Based on the optimized conditions, the MF-SMB experiment was conducted and the assay results for product samples verified the attainment of a ternary separation. The experimental purities and concentrations were also found to agree closely with the model predictions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Optimal design and experimental validation of a modified four-zone SMB process for the separation of a ternary amino acid mixture | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Mun, Sungyong | - |
dc.identifier.doi | 10.1016/j.procbio.2010.04.016 | - |
dc.identifier.scopusid | 2-s2.0-77954089235 | - |
dc.identifier.wosid | 000280382800011 | - |
dc.identifier.bibliographicCitation | PROCESS BIOCHEMISTRY, v.45, no.8, pp.1288 - 1298 | - |
dc.relation.isPartOf | PROCESS BIOCHEMISTRY | - |
dc.citation.title | PROCESS BIOCHEMISTRY | - |
dc.citation.volume | 45 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1288 | - |
dc.citation.endPage | 1298 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | SIMULATED MOVING-BED | - |
dc.subject.keywordPlus | MULTIOBJECTIVE OPTIMIZATION | - |
dc.subject.keywordPlus | GENETIC ALGORITHM | - |
dc.subject.keywordPlus | CHROMATOGRAPHY | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | PARAMETERS | - |
dc.subject.keywordPlus | ENANTIOMER | - |
dc.subject.keywordPlus | 5-ZONE | - |
dc.subject.keywordAuthor | Modified four-zone SMB | - |
dc.subject.keywordAuthor | Ternary separation | - |
dc.subject.keywordAuthor | Experimental validation | - |
dc.subject.keywordAuthor | Process optimization | - |
dc.subject.keywordAuthor | Amino acid mixture | - |
dc.subject.keywordAuthor | Model simulation | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S135951131000156X?via%3Dihub | - |
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