Elevated c-Src and c-Yes expression in malignant skin cancers
DC Field | Value | Language |
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dc.contributor.author | Lee, Jang Hyun | - |
dc.contributor.author | Pyon, Jae-Kyung | - |
dc.contributor.author | Kim, Dong Wook | - |
dc.contributor.author | Lee, Sang Han | - |
dc.contributor.author | Nam, Hae Seon | - |
dc.contributor.author | Kim, Chul Han | - |
dc.contributor.author | Kang, Sang Gue | - |
dc.contributor.author | Lee, Yoon Jin | - |
dc.contributor.author | Park, Mi Youn | - |
dc.contributor.author | Jeong, Dong Jun | - |
dc.contributor.author | Cho, Moon Kyun | - |
dc.date.accessioned | 2022-12-20T16:20:45Z | - |
dc.date.available | 2022-12-20T16:20:45Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 1756-9966 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174397 | - |
dc.description.abstract | Background: Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hyper-activated in many human epithelial cancers. However, only a few studies have attempted to define the expression and role of c-Src and c-Yes in cutaneous carcinomas. Objectives: To investigate the expression of c-Src and c-Yes in cutaneous carcinomas to include malignant melanoma (MM), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Methods: We examined 6 normal skin tissues and 18 malignant skin tumor tissues using western blotting for the expression of c-Src and c-Yes. In another set, 16 specimens of MM, 16 SCCs and 16 BCCs were analyzed for the expression of c-Src and c-Yes using immunohistochemical staining. Results: Western blotting showed that c-Src was expressed in all malignant skin tumors, but not in normal skin, while c-Yes was expressed in MM and SCC, but not in BCC and normal skin. Immunohistochemical staining results of c-Src and c-Yes in MM, SCC, and BCC mirrored those of the western blot analysis. Conclusions: c-Src, rather than c-Yes, plays a key role in the proliferation and progression of malignant skin cancers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | Elevated c-Src and c-Yes expression in malignant skin cancers | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jang Hyun | - |
dc.identifier.doi | 10.1186/1756-9966-29-116 | - |
dc.identifier.scopusid | 2-s2.0-77955944269 | - |
dc.identifier.wosid | 000282345300001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, v.29, pp.1 - 7 | - |
dc.relation.isPartOf | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | - |
dc.citation.title | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | - |
dc.citation.volume | 29 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | COMBINED INHIBITION | - |
dc.subject.keywordPlus | FAMILY KINASES | - |
dc.subject.keywordPlus | MELANOMA-CELLS | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PP60C-SRC | - |
dc.subject.keywordPlus | LINES | - |
dc.subject.keywordPlus | HEAD | - |
dc.identifier.url | https://jeccr.biomedcentral.com/articles/10.1186/1756-9966-29-116 | - |
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