Novel guggulsterone derivative GG-52 inhibits NF-kappa B signaling in intestinal epithelial cells and attenuates acute murine colitis
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Kang, Hyoun Woo | - |
dc.contributor.author | Cha, Mi Yeon | - |
dc.contributor.author | Yoo, Doyoung | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Kim, In-Kyoung | - |
dc.contributor.author | Ku, Jeounghun | - |
dc.contributor.author | Kim, Sunil | - |
dc.contributor.author | Ma, Sang-Ho | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Song, In Sung | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.date.accessioned | 2022-12-20T16:30:56Z | - |
dc.date.available | 2022-12-20T16:30:56Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-07 | - |
dc.identifier.issn | 0023-6837 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174477 | - |
dc.description.abstract | We already showed that the plant sterol guggulsterone has been reported to inhibit nuclear factor-kappa B (NF-kappa B) signaling in intestinal epithelial cells (IECs) and to attenuate dextran sulfate sodium (DSS)-induced colitis. This study investigates the anti-inflammatory effects of novel guggulsterone derivatives on IEC and preventive and therapeutic murine models of DSS-induced colitis. Novel guggulsterone derivates with high lipophilicity were designed and four derivates, including GG-46, GG-50B, GG-52, and GG-53, were synthesized. Two guggulsterone derivatives, GG-50B and GG-52, significantly inhibited the activated NF-kappa B signals and the upregulated expression of interleukin-8 (IL-8) in COLO 205 cells stimulated with tumor necrosis factor-alpha (TNF-alpha). Pretreatment with GG-50B and GG-52 attenuated the increased I kappa B kinase (IKK) and I kappa B alpha phsophorylation induced by TNF-alpha. In preventive and therapeutic models of murine colitis, administration of GG-52 significantly reduced the severity of DSS-induced colitis, as assessed by disease activity index, colon length, and histology. In contrast, GG-50B did not show a significant reduction in the colitis severity. Moreover, the efficacy on attenuating colitis by GG-52 was comparable to that by sulfasalazine or prednisolone. These results indicate that the novel guggulsterone derivative GG-52 blocks NF-kappa B activation in IEC and ameliorates DSS-induced acute murine colitis, which suggests that GG-52 is a potential therapeutic agent for the treatment of inflammatory bowel diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Novel guggulsterone derivative GG-52 inhibits NF-kappa B signaling in intestinal epithelial cells and attenuates acute murine colitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.identifier.doi | 10.1038/labinvest.2010.54 | - |
dc.identifier.scopusid | 2-s2.0-77951249102 | - |
dc.identifier.wosid | 000279342800004 | - |
dc.identifier.bibliographicCitation | LABORATORY INVESTIGATION, v.90, no.7, pp.1004 - 1015 | - |
dc.relation.isPartOf | LABORATORY INVESTIGATION | - |
dc.citation.title | LABORATORY INVESTIGATION | - |
dc.citation.volume | 90 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1004 | - |
dc.citation.endPage | 1015 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | BACTEROIDES-FRAGILIS ENTEROTOXIN | - |
dc.subject.keywordPlus | ACTIVATOR PROTEIN-1 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BACTERIAL | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordAuthor | guggulsterone derivatives | - |
dc.subject.keywordAuthor | inflammatory bowel disease | - |
dc.subject.keywordAuthor | murine colitis | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.identifier.url | https://www.nature.com/articles/labinvest201054 | - |
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