Matrix Metalloproteinase-1 Expression Can Be Upregulated through Mitogen-Activated Protein Kinase Pathway under the Influence of Human Epidermal Growth Factor Receptor 2 Synergized with Estrogen Receptor
DC Field | Value | Language |
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dc.contributor.author | Jung, Hae Hyun | - |
dc.contributor.author | Park, Yeon Hee | - |
dc.contributor.author | Jun, Hyun Jung | - |
dc.contributor.author | Kong, Jeehyun | - |
dc.contributor.author | Kim, Jeong Hoon | - |
dc.contributor.author | Kim, Jung A. | - |
dc.contributor.author | Yun, Jina | - |
dc.contributor.author | Sun, Jong Mu | - |
dc.contributor.author | Won, Young Woong | - |
dc.contributor.author | Lee, Soohyeon | - |
dc.contributor.author | Kim, Seung Tae | - |
dc.contributor.author | Ahn, Jin Seok | - |
dc.contributor.author | Im, Young-Hyuck | - |
dc.date.accessioned | 2022-12-20T16:35:51Z | - |
dc.date.available | 2022-12-20T16:35:51Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2010-07 | - |
dc.identifier.issn | 1541-7786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174523 | - |
dc.description.abstract | In our previous work, Ets-1 upregulates human epidermal growth factor receptor 2 (HER2) induced matrix metalloproteinase 1 (MMP-1) expression. Based on the above knowledge and result, we hypothesized that estrogen receptor (ER) and its signaling pathway may affect MMP-1 expression under the influence of HER2. In addition, we investigated how the HER2 pathway cross-talk with the ER signaling pathway in genomic and nongenomic action of ER using reverse transcription-PCR, Western blot analysis, and ELISA assay. The results showed that ER-alpha expression increased MMP-1 expression under the presence of HER2. These upregulatory effects were mediated mainly by mitogen-activated protein kinase pathway and were reversed by downregulation of HER2 and/or ER. Activator protein DNA binding activity was involved in the MMP-1 expression. In summary, our results showed that ER can upregulate MMP-1 expression under the influence of HER2 in MCF-7 cells. In addition, this upregulatory effect was found to be mediated by mitogen-activated protein kinase pathway. MMP-1 might be an assigned target in interaction between ER and HER2. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.title | Matrix Metalloproteinase-1 Expression Can Be Upregulated through Mitogen-Activated Protein Kinase Pathway under the Influence of Human Epidermal Growth Factor Receptor 2 Synergized with Estrogen Receptor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Won, Young Woong | - |
dc.identifier.doi | 10.1158/1541-7786.MCR-09-0469 | - |
dc.identifier.scopusid | 2-s2.0-77955459810 | - |
dc.identifier.wosid | 000279885600010 | - |
dc.identifier.bibliographicCitation | MOLECULAR CANCER RESEARCH, v.8, no.7, pp.1037 - 1047 | - |
dc.relation.isPartOf | MOLECULAR CANCER RESEARCH | - |
dc.citation.title | MOLECULAR CANCER RESEARCH | - |
dc.citation.volume | 8 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1037 | - |
dc.citation.endPage | 1047 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | AP-1 | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | CROSSTALK | - |
dc.identifier.url | https://aacrjournals.org/mcr/article/8/7/1037/90674/Matrix-Metalloproteinase-1-Expression-Can-Be | - |
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