Treatment Outcomes and Survival Based on Drug Resistance Patterns in Multidrug-resistant Tuberculosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Doh Hyung | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Park, Seung-Kyu | - |
dc.contributor.author | Kong, Suck-Jun | - |
dc.contributor.author | Kim, Young Sam | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Kim, Eun Kyung | - |
dc.contributor.author | Lee, Ki Man | - |
dc.contributor.author | Lee, Sung-Soon | - |
dc.contributor.author | Park, Jae Seuk | - |
dc.contributor.author | Koh, Won-Jung | - |
dc.contributor.author | Lee, Chang-Hoon | - |
dc.contributor.author | Shim, Tae Sun | - |
dc.date.accessioned | 2022-12-20T16:36:23Z | - |
dc.date.available | 2022-12-20T16:36:23Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2010-07 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174526 | - |
dc.description.abstract | Rationale: Few large-scale studies have investigated multidrug-resistant tuberculosis (MDR-TB) treatment outcomes relative to drug-resistance patterns. Objectives: To assess the impact of additional drug resistances on treatment outcomes and long-term survival in a large HIV-negative MDR-TB cohort. Methods: Treatment outcomes and long-term survival of patients with MDR-TB newly diagnosed or retreated in 2000 to 2002 were retrospectively analyzed based on drug-resistance patterns after 5-8 years of follow-up. Measurements and Main Results: Of 1,407 patients with MDR-TB, 75 (5.3%) had extensively drug-resistant TB (XDR-TB,) by the revised definition; 159 (11.3%) had ofloxacin-resistant pre-XDR-TB (pre-XDR-TB.); and 117 (8.3%) had second-line injectable drug (SLID)-resistant pre-XDR-TB (pre-XDR-TB(s)). Patients with XDR-TB, showed the lowest treatment success rate (29.3%) and the poorest long-term survival, and XDR-TB(re) was more strongly associated with long-term mortality than XDR-TB as originally defined (hazards ratio [HR], 3.15; 95% confidence interval [Cl], 2.06-4.83; P < 0.001 vs. HR, 2.15; 95% Cl, 1.49-3.09; P < 0.001). Patients with either form of pre-XDR-TB showed poorer cumulative survival than those with ofloxacin-susceptible/SLID-susceptible MDR-TB (P < 0.05 for each comparison). Although streptomycin susceptibility did not affect the treatment outcomes of patients with pre-XDR-TB, streptomycin-resistant pre-XDR-TB was more strongly associated with long-term mortality than ofloxacin-susceptible/SLID-susceptible MDR-TB (HR, 2.17; 95% Cl, 1.22-3.84; P < 0.008 for preXDR-TB.; and HR, 2.69; 95% Cl, 1.40-5.16; P= 0.003 for pre-XDR-TBs). Conclusions: The revised XDR-TB definition is appropriate for defining patients with MDR-TB with the poorest outcomes. Both pre-XDR-TB(o) and pre-XDR-TBs were independently associated with poor long-term survival in patients with MDR-TB. SM susceptibility was linked to better survival in patients with pre-XDR-TB. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER THORACIC SOC | - |
dc.title | Treatment Outcomes and Survival Based on Drug Resistance Patterns in Multidrug-resistant Tuberculosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hyung | - |
dc.identifier.doi | 10.1164/rccm.200911-1656OC | - |
dc.identifier.scopusid | 2-s2.0-77955861809 | - |
dc.identifier.wosid | 000279709200017 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, v.182, no.1, pp.113 - 119 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | - |
dc.citation.title | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | - |
dc.citation.volume | 182 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 113 | - |
dc.citation.endPage | 119 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | FLUOROQUINOLONES | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | TB | - |
dc.subject.keywordAuthor | tuberculosis | - |
dc.subject.keywordAuthor | multidrug-resistant | - |
dc.subject.keywordAuthor | survival rate | - |
dc.subject.keywordAuthor | treatment outcome | - |
dc.subject.keywordAuthor | drug susceptibility | - |
dc.identifier.url | https://www.atsjournals.org/doi/10.1164/rccm.200911-1656OC | - |
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