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Effects of a Newly Developed Tricyclic PARP-1 Inhibitor, on Ischemic Stroke

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dc.contributor.authorYoo, A. Rum-
dc.contributor.authorKoh, Seong-Ho-
dc.contributor.authorNoh, Min Young-
dc.contributor.authorCho, Goang Won-
dc.contributor.authorPark, Ji-Seon-
dc.contributor.authorKim, Youngchul-
dc.contributor.authorLee, Han-Chang-
dc.contributor.authorKim, Myung-Hwa-
dc.contributor.authorKim, Seung Hyun-
dc.date.accessioned2022-12-20T17:46:43Z-
dc.date.available2022-12-20T17:46:43Z-
dc.date.issued2010-06-
dc.identifier.issn1098-2299-
dc.identifier.issn0272-4391-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174934-
dc.description.abstractPoly(ADP-ribose) polymerase (PARP)-1 plays an important role in the pathogenic mechanism of ischemic stroke. A number of studies have been undertaken to develop PARP-1 inhibitors for clinical use. We report on the newly developed PARP-1 inhibitors, among which 12a showed good activity (IC50) = 7.8 nM in an enzyme-based assay and = 0.73 mu M in a cell-based assay) and pharmacokinetic profiles. Treatment of the middle cerebral artery (MCA) occluded rats with 3 mg/kg 12a reduced infarct volume suggesting that, may be a good candidate for the treatment of ischemic stroke.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherJohn Wiley & Sons Inc.-
dc.titleEffects of a Newly Developed Tricyclic PARP-1 Inhibitor, on Ischemic Stroke-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1002/ddr.20368-
dc.identifier.scopusid2-s2.0-77953887308-
dc.identifier.wosid000279444500005-
dc.identifier.bibliographicCitationDrug Development Research, v.71, no.4, pp 253 - 260-
dc.citation.titleDrug Development Research-
dc.citation.volume71-
dc.citation.number4-
dc.citation.startPage253-
dc.citation.endPage260-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusPOLY(ADP-RIBOSE) SYNTHETASE ACTIVATION-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusBIOLOGICAL EVALUATION-
dc.subject.keywordPlusCEREBRAL-ISCHEMIA-
dc.subject.keywordPlusDNA-DAMAGE-
dc.subject.keywordPlusPOLYMERASE-1-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordPlusPEROXYNITRITE-
dc.subject.keywordAuthorPARP-
dc.subject.keywordAuthorinhibitor-
dc.subject.keywordAuthorstroke-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/ddr.20368-
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