Hyponatraemia induced by low-dose intravenous pulse cyclophosphamide
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Young-Chul | - |
dc.contributor.author | Park, Joon-Sung | - |
dc.contributor.author | Lee, Chang Hwa | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Kim, In-Soon | - |
dc.contributor.author | Kang, Chong Myung | - |
dc.contributor.author | Kim, Gheun-Ho | - |
dc.date.accessioned | 2022-12-20T17:54:35Z | - |
dc.date.available | 2022-12-20T17:54:35Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175002 | - |
dc.description.abstract | Methods. Clinical data were retrospectively analysed from 84 patients (42 lupus nephritis; 42 non-Hodgkin's lymphoma; a total of 112 treatment episodes) admitted for intravenous pulse cyclophosphamide (500-750 mg/m(2)) therapy. In all patients, half-isotonic saline was used for prophylactic hydration. Cyclophosphamide-induced hyponatraemia was defined as serum sodium concentration < 135 mEq/L at 24 hours after the therapy in patients whose basal serum sodium concentrations were normal. Results. After the low-dose intravenous pulse cyclophosphamide, serum sodium concentration significantly decreased from 139.9 +/- 3.5 to 137.9 +/- 5.1 mEq/L (P < 0.001). Cyclophosphamide-induced hyponatraemia occurred in 15 treatment episodes (13.4%) from 12 patients (14.3%). Patients with hyponatraemia were significantly older than those without hyponatraemia (57.3 +/- 14.7 vs. 40.0 +/- 17.0 years, P < 0.01). Hyponatraemia was associated with male sex on univariate analysis (P < 0.05), but not on multivariate analysis. No factors were found to independently predict the occurrence of cyclophosphamide-induced hyponatraemia when multivariate analysis was performed including parameters age, sex, underlying disease, presence or absence of comorbidities associated with hyponatraemia, presence or absence of concurrent medications associated with hyponatraemia and dose of cyclophosphamide. Conclusions. Hyponatraemia occurring after low-dose intravenous pulse cyclophosphamide is not rare, especially when hypotonic solutions are adopted for hydration protocol. Thus, the use of hypotonic fluids should be avoided when using cyclophosphamide. Instead, isotonic solutions should be used if a forced diuresis is required. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Hyponatraemia induced by low-dose intravenous pulse cyclophosphamide | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Chang Hwa | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.contributor.affiliatedAuthor | Kim, Gheun-Ho | - |
dc.identifier.doi | 10.1093/ndt/gfp657 | - |
dc.identifier.scopusid | 2-s2.0-77951689930 | - |
dc.identifier.wosid | 000276994400028 | - |
dc.identifier.bibliographicCitation | NEPHROLOGY DIALYSIS TRANSPLANTATION, v.25, no.5, pp.1520 - 1524 | - |
dc.relation.isPartOf | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.citation.title | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.citation.volume | 25 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1520 | - |
dc.citation.endPage | 1524 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | WATER-INTOXICATION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | VINCRISTINE | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | LEVEL | - |
dc.subject.keywordAuthor | cyclophosphamide | - |
dc.subject.keywordAuthor | hyponatraemia | - |
dc.subject.keywordAuthor | lupus | - |
dc.subject.keywordAuthor | lymphoma | - |
dc.subject.keywordAuthor | risk | - |
dc.identifier.url | https://academic.oup.com/ndt/article/25/5/1520/1838955 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.