Group-specific regional white matter abnormality revealed in diffusion tensor imaging of medial temporal lobe epilepsy without hippocampal sclerosis
DC Field | Value | Language |
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dc.contributor.author | Shon, Young-Min | - |
dc.contributor.author | Kim, Yeong-In | - |
dc.contributor.author | Koo, Bang-Bon | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Kim, Hye J. | - |
dc.contributor.author | Kim, Woo J. | - |
dc.contributor.author | Ahn, Kook J. | - |
dc.contributor.author | Yang, Dong W. | - |
dc.date.accessioned | 2022-12-20T18:17:42Z | - |
dc.date.available | 2022-12-20T18:17:42Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0013-9580 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175188 | - |
dc.description.abstract | P>Purpose: In comparison to temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (TLE-HS), TLE patients without HS (TLE-NH) have a similar clinical course but may result in worse surgical outcome. We investigated whether the clinical features related to the lack of HS in TLE patients (TLE-NH) can be explained by water diffusion abnormalities throughout diffusion tensor imaging (DTI) by voxel-based analysis. Methods: Nineteen patients with TLE-HS (left/right TLE 12:7), 18 patients with TLE-NH (left/right TLE 10:8), and 20 controls were included in the study. By statistical parametric mapping (SPM2), the diffusion properties specific to disease characteristics (TLE-HS vs. TLE-NH) were analyzed. Results: In TLE-HS, we found the areas of increased mean diffusivity (MD) in their ipsilateral temporal and extratemporal areas including the hippocampus, parahippocampal, and frontoparietal regions. Left TLE-HS showed a characteristic MD increase in the ipsilateral posterior cingulum, isthmus of corpus callosum, and contralateral occipital and temporal regions, which was not observed in right TLE-HS group. In left TLE-NH, two regions of increased MD were observed in the ipsilateral posterior fornix (within fusiform gyrus) and posterior cingulum. Right TLE-NH did not show any increased MD. Discussion: In left TLE-NH, we could find the water diffusion change along the posterior cingulum, which was quite different from the extensive abnormality from TLE-HS. In addition, there was a lesion-side-specific distribution (left predominant) of pathology in mesial TLE. This provides a possibility that TLE-NH is a heterogenous or entity different from TLE-HS. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Group-specific regional white matter abnormality revealed in diffusion tensor imaging of medial temporal lobe epilepsy without hippocampal sclerosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Min | - |
dc.identifier.doi | 10.1111/j.1528-1167.2009.02327.x | - |
dc.identifier.scopusid | 2-s2.0-77951656926 | - |
dc.identifier.wosid | 000276245600005 | - |
dc.identifier.bibliographicCitation | EPILEPSIA, v.51, no.4, pp.529 - 535 | - |
dc.relation.isPartOf | EPILEPSIA | - |
dc.citation.title | EPILEPSIA | - |
dc.citation.volume | 51 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 529 | - |
dc.citation.endPage | 535 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | STATISTICAL-ANALYSIS | - |
dc.subject.keywordPlus | ASYMMETRY | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | MORPHOMETRY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | IMAGES | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | MONKEY | - |
dc.subject.keywordAuthor | Diffusion tensor imaging | - |
dc.subject.keywordAuthor | Temporal lobe epilepsy | - |
dc.subject.keywordAuthor | Nonlesional | - |
dc.subject.keywordAuthor | Voxel-based | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02327.x | - |
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