Triad 1 induces apoptosis by p53 activation
DC Field | Value | Language |
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dc.contributor.author | Jung, Jin Hyuk | - |
dc.contributor.author | Lee, Sun-Mi | - |
dc.contributor.author | Bae, Seunghee | - |
dc.contributor.author | Lee, Su-Jae | - |
dc.contributor.author | Park, In-Chul | - |
dc.contributor.author | Jin, Young-Woo | - |
dc.contributor.author | Lee, Jae Ho | - |
dc.contributor.author | An, Sungkwan | - |
dc.date.accessioned | 2022-12-20T18:22:12Z | - |
dc.date.available | 2022-12-20T18:22:12Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175208 | - |
dc.description.abstract | Triad 1 (2 RING [ really interesting new gene] fingers and DRIL [double RING finger linked] 1) is an E3 ligase that induces apoptosis and clonogenic inhibition in myeloid cells through Gfi-1 stabilization. Here we demonstrate that Triad 1 induces apoptosis in several cancer cell lines including MCF7, A549, U2OS, and HCT 116 p53(+/+) cells via its RING ligase activity. Interestingly, in these cancer cells, Triad 1-induced apoptosis is not mediated by Gfi-1 stabilization but is instead p53-dependent. Moreover, Triad 1 promotes transactivation of p53. These results suggest that Triad 1 can induce apoptosis through its ligase activity via p53 activation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Triad 1 induces apoptosis by p53 activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Su-Jae | - |
dc.identifier.doi | 10.1016/j.febslet.2010.03.011 | - |
dc.identifier.scopusid | 2-s2.0-77951294512 | - |
dc.identifier.wosid | 000276529200023 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.584, no.8, pp.1565 - 1570 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 584 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1565 | - |
dc.citation.endPage | 1570 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | RETINOIC ACID | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | STABILIZATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | MDM2 | - |
dc.subject.keywordAuthor | Triad 1 | - |
dc.subject.keywordAuthor | Gfi-1 | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | RING finger | - |
dc.identifier.url | https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2010.03.011 | - |
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