Clinicopathologic significance of cyclooxygenase-2 overexpression in colorectal adenocarcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Se Min | - |
dc.contributor.author | Jun, Young Jin | - |
dc.contributor.author | Na, Woong | - |
dc.contributor.author | Jang, Si-Hyong | - |
dc.contributor.author | Min, Kyueng Whan | - |
dc.contributor.author | Song, Young Soo | - |
dc.contributor.author | Jang, Ki-Seok | - |
dc.contributor.author | Han, Hong Xiu | - |
dc.contributor.author | Lee, Kang Hong | - |
dc.contributor.author | Paik, Seung Sam | - |
dc.date.accessioned | 2022-12-20T18:41:55Z | - |
dc.date.available | 2022-12-20T18:41:55Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 1755-9294 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175308 | - |
dc.description.abstract | Background and aim: Cyclooxygenase-2 (COX-2) plays an important role in colorectal cancer development and is frequently up-regulated in colorectal cancer. The purpose of this study was to investigate COX-2 overexpression in colorectal adenocarcinoma and to evaluate the correlation with the clinicopathological parameters and p53 expression, as well as its effect on patient survival. Methods: We evaluated the expression of COX-2 and p53 on the tissue microarray of 414 colorectal adenocarcinomas by immunohistochemistry. Data was analyzed by Fisher's exact test, χ2-test, one-way ANOVA, Cox regression hazards model and log-rank test with Kaplan-Meier curves. Results: The cytoplasmic COX-2 overexpression was detected in 56.3% of colorectal adenocarcinoma samples. COX-2 overexpression was correlated with favorable clinicopathologic factors in lymph node metastasis (P= 0.002), American Joint Committee on Cancer and Dukes' stage (P= 0.008 and P= 0.017, respectively), and lymphatic invasion (P= 0.001). Other characteristics associated with COX-2 overexpression were colonic site of tumor (P= 0.008) and poor differentiation (P= 0.017). There was no correlation between COX-2 overexpression and p53 expression (P= 0.485). In univariate survival analysis, patients with COX-2 overexpression revealed better overall survival and disease-free survival (P= 0.021 and P= 0.017, respectively, log-rank test). In multivariate survival analysis with the Cox proportional hazards model, COX-2 overexpression was an independent prognostic factor of overall survival and disease-free survival (P= 0.029 and P= 0.039, respectively). Conclusions: COX-2 overexpression was significantly associated with favorable clinicopathologic phenotype and an indicator of better survival in our cohort of colorectal cancer patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.title | Clinicopathologic significance of cyclooxygenase-2 overexpression in colorectal adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Ki-Seok | - |
dc.contributor.affiliatedAuthor | Lee, Kang Hong | - |
dc.contributor.affiliatedAuthor | Paik, Seung Sam | - |
dc.identifier.doi | 10.1111/j.1755-9294.2009.01064.x | - |
dc.identifier.scopusid | 2-s2.0-77955635829 | - |
dc.identifier.bibliographicCitation | Basic and Applied Pathology, v.3, no.1, pp.14 - 20 | - |
dc.relation.isPartOf | Basic and Applied Pathology | - |
dc.citation.title | Basic and Applied Pathology | - |
dc.citation.volume | 3 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 14 | - |
dc.citation.endPage | 20 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Adenocarcinoma | - |
dc.subject.keywordAuthor | Colorectum | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | P53 | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Survival | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1755-9294.2009.01064.x | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.