D-Psicose, a Sweet Monosaccharide, Ameliorate Hyperglycemia, and Dyslipidemia in C57BL/6J db/db Mice
DC Field | Value | Language |
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dc.contributor.author | Baek, S. H. | - |
dc.contributor.author | Park, S. J. | - |
dc.contributor.author | Lee, H. G. | - |
dc.date.accessioned | 2022-12-20T18:45:51Z | - |
dc.date.available | 2022-12-20T18:45:51Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 0022-1147 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175347 | - |
dc.description.abstract | D-psicose has been implicated in glycemic control in recent animal and human studies. In this study, the effects of D-psicose on glycemic responses, insulin release, and lipid profiles were compared with those of D-glucose and D-fructose in a genetic diabetes model. C57BL/6J db/db mice were orally supplemented with 200 mg/kg BW of D-psicose, D-glucose, or D-fructose, respectively, while diabetes control or wild type mice were supplemented with water instead. D-psicose sustained weight gain by about 10% compared to other groups. The initial blood glucose level maintained from 276 to 305 mg/dL during 28 d in the D-psicose group, whereas a 2-fold increase was found in other groups (P < 0.05) among diabetic mice. D-psicose significantly improved glucose tolerance and the areas under the curve (AUC) for glucose among diabetes (P < 0.05), but had no effect on serum insulin concentration. The plasma lipid profile was not changed by supplemental monosacchrides, although the ratio of LDL-cholesterol/HDL-cholesterol was ameliorated by D-psicose. The administration of D-psicose reversed hepatic concentrations of triglyceride (TG) and total cholesterol (TC) by 37.88% and 62.89%, respectively, compared to the diabetes control (P < 0.05). The current findings suggest that D-psicose shows promise as an antidiabetic and may have antidyslipidemic effects in type 2 diabetes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | D-Psicose, a Sweet Monosaccharide, Ameliorate Hyperglycemia, and Dyslipidemia in C57BL/6J db/db Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, H. G. | - |
dc.identifier.doi | 10.1111/j.1750-3841.2009.01434.x | - |
dc.identifier.scopusid | 2-s2.0-77953903384 | - |
dc.identifier.wosid | 000275110200046 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FOOD SCIENCE, v.75, no.2, pp.H49 - H53 | - |
dc.relation.isPartOf | JOURNAL OF FOOD SCIENCE | - |
dc.citation.title | JOURNAL OF FOOD SCIENCE | - |
dc.citation.volume | 75 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | H49 | - |
dc.citation.endPage | H53 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | CHAIN FATTY-ACIDS | - |
dc.subject.keywordPlus | DIETARY D-PSICOSE | - |
dc.subject.keywordPlus | D-FRUCTOSE | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | BIOPRODUCTION | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | EXCRETION | - |
dc.subject.keywordPlus | PRODUCTS | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordAuthor | C57BL/6J db/db mice | - |
dc.subject.keywordAuthor | D-fructose | - |
dc.subject.keywordAuthor | D-glucose | - |
dc.subject.keywordAuthor | D-psicose | - |
dc.subject.keywordAuthor | type 2 diabetes | - |
dc.identifier.url | https://ift.onlinelibrary.wiley.com/doi/10.1111/j.1750-3841.2009.01434.x | - |
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