The p38 MAPK pathway is critical for 5,5 '-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells
DC Field | Value | Language |
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dc.contributor.author | Choi, Kyeong-Hee | - |
dc.contributor.author | Kim, Hyung-Kook | - |
dc.contributor.author | Kim, Jun-Hee | - |
dc.contributor.author | Choi, Eun-Sun | - |
dc.contributor.author | Shin, Ji-Ae | - |
dc.contributor.author | Lee, Syng-Ook | - |
dc.contributor.author | Chintharlapalli, Sudhakar | - |
dc.contributor.author | Safe, Stephen | - |
dc.contributor.author | Abdelrahim, Maen | - |
dc.contributor.author | Kong, Gu | - |
dc.contributor.author | Choi, Hong Seok | - |
dc.contributor.author | Jung, Ji-Youn | - |
dc.contributor.author | Cho, Hyun-Tae | - |
dc.contributor.author | Cho, Nam-Pyo | - |
dc.contributor.author | Cho, Sung-Dae | - |
dc.date.accessioned | 2022-12-20T18:46:52Z | - |
dc.date.available | 2022-12-20T18:46:52Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 0959-8278 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175358 | - |
dc.description.abstract | Cruciferous vegetables contain isothiocyanates including diindolylmethane (DIM) that exhibit cancer chemopreventive effects. We developed a series of synthetic ring-substituted DIM analogs including 5,5'-dibromoDIM that exhibited better inhibitory activity in breast and colon cancer cells than DIM. In this study, we investigated whether 5,5'-dibromoDIM inhibits the proliferation of KB and YD-10B oral squamous carcinoma cell lines. 5,5'-dibromoDIM decreased the cell survival and inhibited the growth of oral cancer cells. Exposure of KB and YD-10B cells to 5,5'-dibromoDIM induced caspase-dependent apoptosis evidenced by poly-ADP ribose polymerase cleavage, accumulation of sub-G(1) population, and nuclear condensation and fragmentation. In addition, apoptotic cell death was correlated with damage to the mitochondrial membrane potential through a decrease in the level of Bcl-2 protein expression. Mechanistic studies showed that mitochondria-dependent apoptosis induced by 5,5'-dibromoDIM was mediated by the p38 mitogen-activated protein kinase pathway but not the ERK1/2 and JNK pathway. These results highlight 5,5'-dibromoDIM as an important chemopreventive agent for the clinical treatment of oral cancer through the p38 mitogen-activated protein kinase pathway. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | The p38 MAPK pathway is critical for 5,5 '-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kong, Gu | - |
dc.identifier.doi | 10.1097/CEJ.0b013e328333d088 | - |
dc.identifier.scopusid | 2-s2.0-76449102161 | - |
dc.identifier.wosid | 000274726200011 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CANCER PREVENTION, v.19, no.2, pp.153 - 159 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CANCER PREVENTION | - |
dc.citation.title | EUROPEAN JOURNAL OF CANCER PREVENTION | - |
dc.citation.volume | 19 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 153 | - |
dc.citation.endPage | 159 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | BREAST-CANCER CELLS | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | BRASSICA VEGETABLES | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | DRUG DISCOVERY | - |
dc.subject.keywordPlus | INDOLE-3-CARBINOL | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | 3,3&apos | - |
dc.subject.keywordPlus | -DIINDOLYLMETHANE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | Bcl-2 | - |
dc.subject.keywordAuthor | 5,5 &apos | - |
dc.subject.keywordAuthor | -dibromodiindolylmethane | - |
dc.subject.keywordAuthor | human oral squamous carcinoma cells | - |
dc.subject.keywordAuthor | mitochondrial membrane potentials | - |
dc.subject.keywordAuthor | p38 mitogen-activated protein kinase | - |
dc.identifier.url | https://journals.lww.com/eurjcancerprev/Fulltext/2010/03000/The_p38_MAPK_pathway_is_critical_for.11.aspx | - |
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