Use of peptide for selective and sensitive detection of an Anthrax biomarker via peptide recognition and surface-enhanced Raman scattering
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Kyungtag | - |
dc.contributor.author | Haes, Amanda J. | - |
dc.contributor.author | Park, Hye-Yeon | - |
dc.contributor.author | Nah, Sanghee | - |
dc.contributor.author | Kim, Joungmok | - |
dc.contributor.author | Chung, Hoeil | - |
dc.contributor.author | Yoon, Moon-Young | - |
dc.contributor.author | Han, Sung-Hwan | - |
dc.date.accessioned | 2022-12-20T19:08:18Z | - |
dc.date.available | 2022-12-20T19:08:18Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-02 | - |
dc.identifier.issn | 0377-0486 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175486 | - |
dc.description.abstract | A short 16-amino acid peptide has been used in place of an antibody to selectively detect the specific Anthrax biomarker, protective antigen (PA), using surface-enhanced Raman scattering (SERS). Peptides are more stable than antibodies under various biological conditions and are easily synthesized for a specific target. A peptide that has high affinity to PA was conjugated onto gold nanoparticles along with a Raman reporter and then incubated in various concentrations of PA. Parallel studies in which the peptide sequence was replaced with an antibody were performed to compare the performance of the two methodologies. Both the peptide and antibody functionalized nanoparticles were able to specifically detect PA concentrations down to 6.1 fM. These results demonstrate that these short, robust peptides can be used in the place of traditional antibodies to specifically recognize target biomarkers in the field for the potential diagnosis of disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Use of peptide for selective and sensitive detection of an Anthrax biomarker via peptide recognition and surface-enhanced Raman scattering | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Hoeil | - |
dc.identifier.doi | 10.1002/jrs.2591 | - |
dc.identifier.scopusid | 2-s2.0-77049099336 | - |
dc.identifier.wosid | 000275679700001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RAMAN SPECTROSCOPY, v.41, no.2, pp.121 - 124 | - |
dc.relation.isPartOf | JOURNAL OF RAMAN SPECTROSCOPY | - |
dc.citation.title | JOURNAL OF RAMAN SPECTROSCOPY | - |
dc.citation.volume | 41 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 121 | - |
dc.citation.endPage | 124 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Spectroscopy | - |
dc.relation.journalWebOfScienceCategory | Spectroscopy | - |
dc.subject.keywordPlus | PHAGE DISPLAY | - |
dc.subject.keywordPlus | IMMUNOASSAY | - |
dc.subject.keywordPlus | SPORES | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | LABELS | - |
dc.subject.keywordPlus | SERS | - |
dc.subject.keywordAuthor | Anthrax | - |
dc.subject.keywordAuthor | protective antigen | - |
dc.subject.keywordAuthor | peptide | - |
dc.subject.keywordAuthor | SERS | - |
dc.identifier.url | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jrs.2591 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.