Control of Osteogenic Differentiation and Mineralization of Human Mesenchymal Stem Cells on Composite Nanofibers Containing Poly [lactic-co-(glycolic acid)] and Hydroxyapatite
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ji Hye | - |
dc.contributor.author | Rim, Nae Gyune | - |
dc.contributor.author | Jung, Hyun Suk | - |
dc.contributor.author | Shin, Heungsoo | - |
dc.date.accessioned | 2022-12-20T19:11:31Z | - |
dc.date.available | 2022-12-20T19:11:31Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-02 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175516 | - |
dc.description.abstract | We fabricated composite fibrous scaffolds from blends of poly (lactide-co-glycolide) (PLGA) and nano-sized hydroxyapatite (HA) via electrospinning. SEM-EDX and AFM analysis demonstrated that HA was homogeneously dispersed in the nanofibers, and the roughness increased along with the amount of incorporated HA. When hMSCs were cultured on these PLGA/HA composite nanofibers, we found that incorporation of HA on the nanofibers did not affect cell viability whereas increased ALP activity and expression of osteogenic genes as well as the calcium mineralization of hMSCs. Our results indicate that the composite nanofibers can be offered as a potential bone regenerative biomaterial for stem cell based therapies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Control of Osteogenic Differentiation and Mineralization of Human Mesenchymal Stem Cells on Composite Nanofibers Containing Poly [lactic-co-(glycolic acid)] and Hydroxyapatite | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Heungsoo | - |
dc.identifier.doi | 10.1002/mabi.200900169 | - |
dc.identifier.scopusid | 2-s2.0-76649103732 | - |
dc.identifier.wosid | 000274990100007 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, v.10, no.2, pp.173 - 182 | - |
dc.relation.isPartOf | MACROMOLECULAR BIOSCIENCE | - |
dc.citation.title | MACROMOLECULAR BIOSCIENCE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 173 | - |
dc.citation.endPage | 182 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | GUIDED TISSUE REGENERATION | - |
dc.subject.keywordPlus | BETA-TRICALCIUM PHOSPHATE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BONE REGENERATION | - |
dc.subject.keywordPlus | PROGENITOR CELLS | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | NANOCOMPOSITE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | OSTEOBLASTS | - |
dc.subject.keywordPlus | GELATIN | - |
dc.subject.keywordAuthor | differential scanning calorimetry | - |
dc.subject.keywordAuthor | human mesenchymal stem cells | - |
dc.subject.keywordAuthor | hydroxyapatite | - |
dc.subject.keywordAuthor | fibers | - |
dc.subject.keywordAuthor | osteogenic differentiation | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/mabi.200900169 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.