Smoking Increases Rheumatoid Arthritis Susceptibility in Individuals Carrying the HLA-DRB1 Shared Epitope, Regardless of Rheumatoid Factor or Anti-Cyclic Citrullinated Peptide Antibody Status
DC Field | Value | Language |
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dc.contributor.author | Bang, So-Young | - |
dc.contributor.author | Lee, Kyoung-Ho | - |
dc.contributor.author | Cho, Soo-Kyung | - |
dc.contributor.author | Lee, Hye-Soon | - |
dc.contributor.author | Lee, Kyung Wha | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.date.accessioned | 2022-12-20T19:13:49Z | - |
dc.date.available | 2022-12-20T19:13:49Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2010-02 | - |
dc.identifier.issn | 0004-3591 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175532 | - |
dc.description.abstract | Objective. Smoking is associated with rheumatoid arthritis (RA) in individuals with the HLA-DRB1 shared epitope (SE). SE alleles have been shown to be predominantly associated with anti-cyclic citrullinated peptide (anti-CCP)-positive RA. These risk factors have not been identified for anti-CCP-negative RA. The aim of this study was to investigate whether SE-containing HLA-DRB1 alleles, smoking, or the combination of these factors contributes to the development of RA, depending on the presence or absence of serologic markers, in a Korean population. Methods. All of the patients with RA (n = 1,482) and all of the control subjects (n = 1,119) were Korean. Four-digit HLA-DRB1 typing was performed by a conventional polymerase chain reaction-sequence-based typing method. Information about smoking history was obtained through a questionnaire. The patients with RA were tested for anti-CCP antibodies and rheumatoid factor (RF). Results. The SE alleles had significant effects on anti-CCP antibody and RF formation. The DRB1*0901 allele was associated with the presence of anti-CCP antibodies (odds ratio [OR] 2.49) and RF (OR 2.09). SE CCP-positive and anti-CCP-negative RA. The combination of smoking and double copies of the SE allele increased the risk of anti-CCP-positive RA 36.11-fold and increased the risk of anti-CCP-negative RA 12.29-fold, compared with the risk among nonsmokers not carrying SE alleles. Interactions between SE alleles and smoking were observed for both anti-CCP-positive and RF-positive RA, although the associations of RF-positive RA could be consequences of the underlying anti-CCP antibody status. Conclusion. We demonstrated that the combination of SE alleles and smoking is associated with RA susceptibility regardless of anti-CCP antibody or RF status, but that the combination shows stronger effects in anti-CCP-positive/RF-positive patients with RA than in anti-CCP-negative/RF-negative patients with RA. The SE-smoking interactions were present in anti-CCP-positive and RF-positive RA. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Smoking Increases Rheumatoid Arthritis Susceptibility in Individuals Carrying the HLA-DRB1 Shared Epitope, Regardless of Rheumatoid Factor or Anti-Cyclic Citrullinated Peptide Antibody Status | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bang, So-Young | - |
dc.contributor.affiliatedAuthor | Cho, Soo-Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Hye-Soon | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1002/art.27272 | - |
dc.identifier.scopusid | 2-s2.0-75749143915 | - |
dc.identifier.wosid | 000279432100011 | - |
dc.identifier.bibliographicCitation | ARTHRITIS AND RHEUMATISM, v.62, no.2, pp.369 - 377 | - |
dc.relation.isPartOf | ARTHRITIS AND RHEUMATISM | - |
dc.citation.title | ARTHRITIS AND RHEUMATISM | - |
dc.citation.volume | 62 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 369 | - |
dc.citation.endPage | 377 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | CLASS-II GENES | - |
dc.subject.keywordPlus | CIGARETTE-SMOKING | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | ALLELES | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | HYPOTHESIS | - |
dc.subject.keywordPlus | TWINS | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | POPULATION | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/art.27272 | - |
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