KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression
DC Field | Value | Language |
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dc.contributor.author | Leem, Dae-Ho | - |
dc.contributor.author | Choi, Kyeong-Hee | - |
dc.contributor.author | Han, Hye-Suk | - |
dc.contributor.author | Kim, Jun-Hee | - |
dc.contributor.author | Shin, Ji-Ae | - |
dc.contributor.author | Choi, Eun-Sun | - |
dc.contributor.author | Shim, Jung-Hyun | - |
dc.contributor.author | Kong, Gu | - |
dc.contributor.author | Min, Yong-Ki | - |
dc.contributor.author | Nam, Jeong-Seok | - |
dc.contributor.author | Oh, Seung Hyun | - |
dc.contributor.author | Kim, Kyoung-A | - |
dc.contributor.author | Kwon, Ki Han | - |
dc.contributor.author | Cho, Nam-Pyo | - |
dc.contributor.author | Cho, Sung-Dae | - |
dc.date.accessioned | 2022-12-20T19:17:44Z | - |
dc.date.available | 2022-12-20T19:17:44Z | - |
dc.date.created | 2022-08-27 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.issn | 0959-8278 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175571 | - |
dc.description.abstract | In a previous study, we demonstrated that cyclooxygenase-2 (COX-2) is overexpressed in Korean patients having oral cancer. The goal of this study was to study whether KO-202125 (KO), a sauristolactam derivative in KB human oral squamous carcinoma cells, inhibits the activity of COX-2 enzyme and induces apoptotic cell death. In this study, it was shown that KO inhibited COX-2 mRNA and protein and its catalytic activity (prostaglandin EA but not COX-1. The anti proliferative effect of KO on KB cells was also examined. The results showed that KO significantly decreased the number of viable cells and showed morphological changes in a concentration-dependent manner. The decrease in cell number was associated with apoptotic cell death evidenced by cleaved poly ADP ribose polymerase (PARP), nuclear fragmentation, sub-G, population and annexin V positivity. Interestingly, KO is more potent than celecoxib, which is a well-known selective COX-2 inhibitor, although more studies are needed to prove it. Altogether, these results show that KO can act as a potent antioral cancer drug candidate by regulating COX-2 activity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kong, Gu | - |
dc.identifier.doi | 10.1097/CEJ.0b013e328333d09e | - |
dc.identifier.scopusid | 2-s2.0-75149141794 | - |
dc.identifier.wosid | 000272952200004 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CANCER PREVENTION, v.19, no.1, pp.23 - 30 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CANCER PREVENTION | - |
dc.citation.title | EUROPEAN JOURNAL OF CANCER PREVENTION | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 23 | - |
dc.citation.endPage | 30 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | PROSTATE-CANCER CELLS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SAURURUS-CHINENSIS | - |
dc.subject.keywordPlus | TRANSACTIVATION ACTIVITY | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | ADENOCARCINOMAS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | celecoxib | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | KB human oral squamous carcinoma cells | - |
dc.subject.keywordAuthor | KO-202125 | - |
dc.subject.keywordAuthor | PGE(2) | - |
dc.identifier.url | https://journals.lww.com/eurjcancerprev/Fulltext/2010/01000/KO_202125,_a_sauristolactam_derivate,_induces.4.aspx | - |
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