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Oral Administration of 1,4-Aryl-2-mercaptoimidazole Inhibits T-Cell Proliferation and Reduces Clinical Severity in the Murine Experimental Autoimmune Encephalomyelitis Model

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dc.contributor.authorJung, Eun Joo-
dc.contributor.authorHur, Minkyu-
dc.contributor.authorKim, Young Lim-
dc.contributor.authorLee, Ge Hyeong-
dc.contributor.authorKim, Jeongmin-
dc.contributor.authorKim, Ikyon-
dc.contributor.authorLee, MinWoo-
dc.contributor.authorHan, Ho-Kyun-
dc.contributor.authorKim, Mi-Soon-
dc.contributor.authorHwang, Sejin-
dc.contributor.authorKim, Sungjoo-
dc.contributor.authorWoo, A. Mi-
dc.contributor.authorYoon, Yeup-
dc.contributor.authorPark, Heon Jin-
dc.contributor.authorWon, Jonghwa-
dc.date.accessioned2022-12-20T19:44:57Z-
dc.date.available2022-12-20T19:44:57Z-
dc.date.created2022-08-26-
dc.date.issued2009-12-
dc.identifier.issn0022-3565-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175750-
dc.description.abstractT cells play a pivotal role in the initiation and progression of multiple sclerosis. We have found that 1,4-aryl-2-mercaptoimidazole (KRM-III) inhibited T-cell antigen receptor- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of 5 mu M. The KRM-III-mediated inhibitory effect was specific for NFAT activation but not for nuclear factor kappa B. Oral administration of 90 mg/kg KRM-III resulted in complete abrogation of anti-CD3 antibody-induced T-cell activation and a 45.8% reduction in footpad swelling in bovine serum albumin-induced delayed-type hypersensitivity. In the murine experimental autoimmune encephalomyelitis (EAE) model, oral administration of KRM-III significantly attenuated the severity of disease when given before or after disease onset. Draining lymph node cells from KRM-III-treated mice showed markedly reduced proliferation in response to myelin oligodendrocyte glycoprotein peptide. Histological analysis indicated that KRM-III reduced the infiltration of inflammatory cells to the white matter of spinal lumbar cords. These results demonstrate that KRM-III efficiently inhibits T-cell activation and inflammatory responses and lessens EAE clinical signs, which suggest KRM-III as a potential lead compound for the treatment of T-cell driven autoimmune diseases.-
dc.language영어-
dc.language.isoen-
dc.publisherAMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS-
dc.titleOral Administration of 1,4-Aryl-2-mercaptoimidazole Inhibits T-Cell Proliferation and Reduces Clinical Severity in the Murine Experimental Autoimmune Encephalomyelitis Model-
dc.typeArticle-
dc.contributor.affiliatedAuthorHwang, Sejin-
dc.identifier.doi10.1124/jpet.109.154948-
dc.identifier.scopusid2-s2.0-73349127476-
dc.identifier.wosid000272093400026-
dc.identifier.bibliographicCitationJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, v.331, no.3, pp.1005 - 1013-
dc.relation.isPartOfJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS-
dc.citation.titleJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS-
dc.citation.volume331-
dc.citation.number3-
dc.citation.startPage1005-
dc.citation.endPage1013-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusMYELIN BASIC-PROTEIN-
dc.subject.keywordPlusEXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS-
dc.subject.keywordPlusMULTIPLE-SCLEROSIS-
dc.subject.keywordPlusPROTEOLIPID PROTEIN-
dc.subject.keywordPlusSELF-RECOGNITION-
dc.subject.keywordPlusEPITOPE-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusCLONES-
dc.subject.keywordPlusDEMYELINATION-
dc.subject.keywordPlusPROGRESSION-
dc.identifier.urlhttps://jpet.aspetjournals.org/content/331/3/1005-
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