Oral Administration of 1,4-Aryl-2-mercaptoimidazole Inhibits T-Cell Proliferation and Reduces Clinical Severity in the Murine Experimental Autoimmune Encephalomyelitis Model
DC Field | Value | Language |
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dc.contributor.author | Jung, Eun Joo | - |
dc.contributor.author | Hur, Minkyu | - |
dc.contributor.author | Kim, Young Lim | - |
dc.contributor.author | Lee, Ge Hyeong | - |
dc.contributor.author | Kim, Jeongmin | - |
dc.contributor.author | Kim, Ikyon | - |
dc.contributor.author | Lee, MinWoo | - |
dc.contributor.author | Han, Ho-Kyun | - |
dc.contributor.author | Kim, Mi-Soon | - |
dc.contributor.author | Hwang, Sejin | - |
dc.contributor.author | Kim, Sungjoo | - |
dc.contributor.author | Woo, A. Mi | - |
dc.contributor.author | Yoon, Yeup | - |
dc.contributor.author | Park, Heon Jin | - |
dc.contributor.author | Won, Jonghwa | - |
dc.date.accessioned | 2022-12-20T19:44:57Z | - |
dc.date.available | 2022-12-20T19:44:57Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 0022-3565 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175750 | - |
dc.description.abstract | T cells play a pivotal role in the initiation and progression of multiple sclerosis. We have found that 1,4-aryl-2-mercaptoimidazole (KRM-III) inhibited T-cell antigen receptor- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of 5 mu M. The KRM-III-mediated inhibitory effect was specific for NFAT activation but not for nuclear factor kappa B. Oral administration of 90 mg/kg KRM-III resulted in complete abrogation of anti-CD3 antibody-induced T-cell activation and a 45.8% reduction in footpad swelling in bovine serum albumin-induced delayed-type hypersensitivity. In the murine experimental autoimmune encephalomyelitis (EAE) model, oral administration of KRM-III significantly attenuated the severity of disease when given before or after disease onset. Draining lymph node cells from KRM-III-treated mice showed markedly reduced proliferation in response to myelin oligodendrocyte glycoprotein peptide. Histological analysis indicated that KRM-III reduced the infiltration of inflammatory cells to the white matter of spinal lumbar cords. These results demonstrate that KRM-III efficiently inhibits T-cell activation and inflammatory responses and lessens EAE clinical signs, which suggest KRM-III as a potential lead compound for the treatment of T-cell driven autoimmune diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS | - |
dc.title | Oral Administration of 1,4-Aryl-2-mercaptoimidazole Inhibits T-Cell Proliferation and Reduces Clinical Severity in the Murine Experimental Autoimmune Encephalomyelitis Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Sejin | - |
dc.identifier.doi | 10.1124/jpet.109.154948 | - |
dc.identifier.scopusid | 2-s2.0-73349127476 | - |
dc.identifier.wosid | 000272093400026 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, v.331, no.3, pp.1005 - 1013 | - |
dc.relation.isPartOf | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | - |
dc.citation.title | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | - |
dc.citation.volume | 331 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1005 | - |
dc.citation.endPage | 1013 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MYELIN BASIC-PROTEIN | - |
dc.subject.keywordPlus | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | - |
dc.subject.keywordPlus | MULTIPLE-SCLEROSIS | - |
dc.subject.keywordPlus | PROTEOLIPID PROTEIN | - |
dc.subject.keywordPlus | SELF-RECOGNITION | - |
dc.subject.keywordPlus | EPITOPE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CLONES | - |
dc.subject.keywordPlus | DEMYELINATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.identifier.url | https://jpet.aspetjournals.org/content/331/3/1005 | - |
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