A Functional SNP of the Interleukin-18 Gene Is Associated with the Presence of Hepatocellular Carcinoma in Hepatitis B Virus-Infected Patients
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong Seok | - |
dc.contributor.author | Cheong, Jae Youn | - |
dc.contributor.author | Cho, Sung Won | - |
dc.contributor.author | Lee, Kee Myung | - |
dc.contributor.author | Hwang, Jae Chul | - |
dc.contributor.author | Oh, Bermseok | - |
dc.contributor.author | Kimm, Kuchan | - |
dc.contributor.author | Lee, Jung A. | - |
dc.contributor.author | Park, Byung Lae | - |
dc.contributor.author | Cheong, Hyun Sub | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Kim, Jin Hong | - |
dc.date.accessioned | 2022-12-20T19:59:48Z | - |
dc.date.available | 2022-12-20T19:59:48Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175782 | - |
dc.description.abstract | The natural course of hepatitis B virus (HBV) infection is likely related to host immune factors. Interleukin-18 (IL-18) plays a significant role in immune defense. This study was undertaken to determine the association between the presence of hepatocellular carcinoma (HCC) and single-nucleotide polymorphisms (SNPs) in the IL-18 gene in HBV-infected patients. Between March 2002 and December 2004, 730 Korean subjects were enrolled in two different groups: (1) chronic carrier without HCC (n = 637) and (2) HCC (n = 93). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions -667G > T, -148G > C, +8925C > G, and +13925A > C in the study subjects. To evaluate the functional significance of SNPs in the IL-18 gene promoter region, we performed a reporter gene assay in HepG2 and Hep3B cells transfected with different alleles. The IL-18 -148C allele, +8925G allele, +13925C allele, and haplotype 3 (TCGC) were associated with the presence of HCC in codominant and dominant models. Furthermore, functional analyses using the reporter gene assay revealed that the -148C allele conferred significantly lower promoter activity. This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 gene are associated with the presence of HCC and the 148G > C SNP is functionally important in determining disease outcome. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | A Functional SNP of the Interleukin-18 Gene Is Associated with the Presence of Hepatocellular Carcinoma in Hepatitis B Virus-Infected Patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong Seok | - |
dc.identifier.doi | 10.1007/s10620-009-0970-6 | - |
dc.identifier.scopusid | 2-s2.0-70450198384 | - |
dc.identifier.wosid | 000271923300026 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, v.54, no.12, pp.2722 - 2728 | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.citation.title | DIGESTIVE DISEASES AND SCIENCES | - |
dc.citation.volume | 54 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2722 | - |
dc.citation.endPage | 2728 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | CYTOTOXIC T-LYMPHOCYTES | - |
dc.subject.keywordPlus | GAMMA-INDUCING FACTOR | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISMS | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | FAS LIGAND | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | IL-18 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Hepatitis B | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | Single-nucleotide polymorphism | - |
dc.subject.keywordAuthor | Interleukin-18 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10620-009-0970-6 | - |
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