Functional assessment of Nramp-like metal transporters and manganese in Caenorhabditis elegans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bandyopadhyay, Jaya | - |
dc.contributor.author | Song, Hyun-Ok | - |
dc.contributor.author | Park, Byung-Jae | - |
dc.contributor.author | Singaravelu, Gunasekaran | - |
dc.contributor.author | Sun, Ju Lee | - |
dc.contributor.author | Ahnn, Joohong | - |
dc.contributor.author | Cho, Jeong Hoon | - |
dc.date.accessioned | 2022-12-20T20:00:58Z | - |
dc.date.available | 2022-12-20T20:00:58Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175792 | - |
dc.description.abstract | Nramp1 (natural resistance-associated macrophage protein-1) is a functionally conserved iron-manganese transporter in macrophages. Manganese (Mn), a superoxide scavenger, is required in trace amounts and functions as a cofactor for most antioxidants. Three Nramp homologs. smf-1, smf-2, and smf-3, have been identified thus far in the nematode Caenorhabditis elegans. A GFP promoter assay revealed largely intestinal expression of the smf genes from early embryonic through adult stages. In addition, smf deletion mutants showed increased sensitivity to excess Mn and mild sensitivity to EDTA. Interestingly, these smf deletion mutants demonstrated hypersensitivity to the pathogen Staphylococcus aureus, an effect that was rescued by Mn feeding or knockdown of the Golgi calcium/manganese ATPase, pmr-1, indicating that Mn uptake is essential for the innate immune system. This reversal of pathogen sensitivity by Mn feeding suggests a protective and therapeutic role of Mn in pathogen evasion systems. We propose that the C elegans intestinal lumen may mimic the mammalian macrophage phagosome and thus could be a simple model for studying Mn-mediated innate immunity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Functional assessment of Nramp-like metal transporters and manganese in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahnn, Joohong | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.09.082 | - |
dc.identifier.scopusid | 2-s2.0-70349973427 | - |
dc.identifier.wosid | 000271295500026 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.390, no.1, pp.136 - 141 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 390 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 136 | - |
dc.citation.endPage | 141 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | Caenorhabditis elegans Nramp homologs | - |
dc.subject.keywordAuthor | Mn feeding | - |
dc.subject.keywordAuthor | Pathogen | - |
dc.subject.keywordAuthor | Caenorhabditis elegans intestine | - |
dc.subject.keywordAuthor | Innate immunity | - |
dc.subject.keywordAuthor | pmr-1 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X09018919?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.