Identification of TRPM7 channels in human intestinal interstitial cells of Cajal
DC Field | Value | Language |
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dc.contributor.author | Kim, Byung Joo | - |
dc.contributor.author | Park, Kyu Joo | - |
dc.contributor.author | Kim, Hyung Woo | - |
dc.contributor.author | Choi, Seok | - |
dc.contributor.author | Jun, Jae Yeoul | - |
dc.contributor.author | Chang, In Youb | - |
dc.contributor.author | Jeon, Ju-Hong | - |
dc.contributor.author | So, Insuk | - |
dc.contributor.author | Kim, Seon Jeong | - |
dc.date.accessioned | 2022-12-20T20:03:23Z | - |
dc.date.available | 2022-12-20T20:03:23Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175796 | - |
dc.description.abstract | AIM: To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 (TRPM7) in the human gastrointestinal (GI) tract. METHODS: Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohistochemistry was used to identify TRPM7 channels in interstitial cells of Cajal (ICCs). RESULTS: The human GI tract generated slow electrical waves and had ICCs which functioned as pacemaker cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB (2-aminoethoxydiphenyl borate) and La3+, TRPM7 channel blockers, inhibited the slow waves. Also, TRPM7 channels were expressed in ICCs in human tissue. CONCLUSION: These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the generation of the slow waves. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.title | Identification of TRPM7 channels in human intestinal interstitial cells of Cajal | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Seon Jeong | - |
dc.identifier.doi | 10.3748/wjg.15.5799 | - |
dc.identifier.scopusid | 2-s2.0-74049162064 | - |
dc.identifier.wosid | 000272690000007 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, v.15, no.46, pp.5799 - 5804 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 15 | - |
dc.citation.number | 46 | - |
dc.citation.startPage | 5799 | - |
dc.citation.endPage | 5804 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | MURINE SMALL-INTESTINE | - |
dc.subject.keywordPlus | C-KIT | - |
dc.subject.keywordPlus | ELECTRICAL RHYTHMICITY | - |
dc.subject.keywordPlus | GASTROINTESTINAL-TRACT | - |
dc.subject.keywordPlus | PACEMAKER CURRENTS | - |
dc.subject.keywordPlus | GENERATE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | STOMACH | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | Electrophysiology | - |
dc.subject.keywordAuthor | Interstitial cells of Cajal | - |
dc.subject.keywordAuthor | TRPM cation channels | - |
dc.subject.keywordAuthor | Transient receptor potential melastatin-type 7 protein | - |
dc.subject.keywordAuthor | Human | - |
dc.subject.keywordAuthor | Gastrointestinal tract | - |
dc.identifier.url | https://www.wjgnet.com/1007-9327/full/v15/i46/5799.htm | - |
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