Expression of Occludin in Testis and Epididymis of Wild Rabbits, Lepus sinensis coreanus
DC Field | Value | Language |
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dc.contributor.author | Yoon, Seong-Il | - |
dc.contributor.author | Park, Chan Jin | - |
dc.contributor.author | Nah, Won Heum | - |
dc.contributor.author | Gye, Myung Chan | - |
dc.date.accessioned | 2022-12-20T20:33:12Z | - |
dc.date.available | 2022-12-20T20:33:12Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-10 | - |
dc.identifier.issn | 0936-6768 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176067 | - |
dc.description.abstract | Contents Tight junctions (TJs) in inter-Sertoli junctional areas and epididymal epithelia build up the blood-testis barrier (BTB) and the blood-epididymal barrier (BEB), respectively. In this study, the expression of occludin, an integral member of the TJs, was examined in testis and different regions of epididymis of Lepus sinensis coreanus, an Korean wild rabbit species. In testis, intense occludin immunoreactivity was found in the basally located inter-Sertoli junctional area together with diffused immunoreactivity of occludin in the cytoplasm of Sertoli cells. It can be suggested that occludin is one of the robust elements of BTB in seminiferous tubules of rabbit testis. In proximal and distal caput epididymis, occludin immunoreactivity was found in the lateral as well as apical contacts of epithelial cells. In corpus epididymis, intense occludin immunoreactivity was found in the basolateral as well as apical contacts of epithelial cells together with cytoplasmic signal. In cauda epididymis, occludin immunoreactivity in luminal epithelia was relatively strong but largely found in the cytoplasm. This suggests that intriguing regulatory mechanisms differentially recruit occludin to the TJ in the different regions of epididymal epithelia. The differences in the subcellular localization as well as expression levels of occludin among the epididymal segments may reflect differential paracellular permeability of epithelia along the epididymal tubules and be correlated with sperm maturation in rabbit. In Western blot, a major form of occludin was MW 62 kDa together with small fragments of MW 34-39 kDa in testis and epididymis, suggesting the peptide cleavage of occludin. This is the first report on the molecular nature of TJs in a wild rabbit testis and epididymis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Expression of Occludin in Testis and Epididymis of Wild Rabbits, Lepus sinensis coreanus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Gye, Myung Chan | - |
dc.identifier.doi | 10.1111/j.1439-0531.2008.01064.x | - |
dc.identifier.scopusid | 2-s2.0-70349193239 | - |
dc.identifier.wosid | 000269877800004 | - |
dc.identifier.bibliographicCitation | REPRODUCTION IN DOMESTIC ANIMALS, v.44, no.5, pp.745 - 750 | - |
dc.relation.isPartOf | REPRODUCTION IN DOMESTIC ANIMALS | - |
dc.citation.title | REPRODUCTION IN DOMESTIC ANIMALS | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 745 | - |
dc.citation.endPage | 750 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Reproductive Biology | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Dairy & Animal Science | - |
dc.relation.journalWebOfScienceCategory | Reproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | CELL TIGHT JUNCTION | - |
dc.subject.keywordPlus | TRANSEPITHELIAL ELECTRICAL-RESISTANCE | - |
dc.subject.keywordPlus | MOUSE SERTOLI-CELLS | - |
dc.subject.keywordPlus | POSTNATAL-DEVELOPMENT | - |
dc.subject.keywordPlus | ZONULA OCCLUDENS-1 | - |
dc.subject.keywordPlus | PROTEIN OCCLUDIN | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | RAT | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1439-0531.2008.01064.x | - |
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