alpha-Tocopherol-loaded Ca-pectinate microcapsules: Optimization, in vitro release, and bioavailability
DC Field | Value | Language |
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dc.contributor.author | Song, Young-Bin | - |
dc.contributor.author | Lee, Ji-Soo | - |
dc.contributor.author | Lee, Hyeon Gyu | - |
dc.date.accessioned | 2022-12-20T20:40:12Z | - |
dc.date.available | 2022-12-20T20:40:12Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-10 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176135 | - |
dc.description.abstract | We used response surface methodology to optimize microcapsule preparation conditions, including the ratio of pectin:a-tocopherol (TP) (X-1), emulsifier concentration (X-2), and CaCl2 concentration (X-3) for maximal entrapment efficiency (EE) of TP-loaded Ca-pectinate microcapsules. The values of X-1, X-2, and X-3, optimized for maximal EE were a ratio of 9.7:6.3, and 1.33% and 5.09%, respectively. The experimental results obtained from the optimum formulation agreed with the predicted results, indicating the usefulness of models for EE. TP release from the Ca-pectinate microcapsules prepared according to the optimized conditions was slow and incomplete in simulated gastric fluid, whereas it was relatively rapid and considerably sustained in simulated intestinal fluid. An in vivo release study revealed that physical entrapment of TP within Ca-pectinate microcapsules can be a good technique to demonstrate the sustained release pattern of TP and to improve the bioavailability for TP following oral administration. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | alpha-Tocopherol-loaded Ca-pectinate microcapsules: Optimization, in vitro release, and bioavailability | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyeon Gyu | - |
dc.identifier.doi | 10.1016/j.colsurfb.2009.06.014 | - |
dc.identifier.scopusid | 2-s2.0-68549115168 | - |
dc.identifier.wosid | 000269598900034 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.73, no.2, pp.394 - 398 | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 73 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 394 | - |
dc.citation.endPage | 398 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | VITAMIN-E | - |
dc.subject.keywordPlus | GEL BEADS | - |
dc.subject.keywordPlus | CALCIUM PECTINATE | - |
dc.subject.keywordPlus | DELIVERY-SYSTEM | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | ALGINATE | - |
dc.subject.keywordPlus | GELATIN | - |
dc.subject.keywordPlus | PELLETS | - |
dc.subject.keywordAuthor | alpha-Tocopherol | - |
dc.subject.keywordAuthor | Response surface methodology | - |
dc.subject.keywordAuthor | Entrapment efficiency | - |
dc.subject.keywordAuthor | In vitro release | - |
dc.subject.keywordAuthor | Bioavailability | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S092777650900263X?via%3Dihub | - |
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