Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model
DC Field | Value | Language |
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dc.contributor.author | Cho, Nam-Pyo | - |
dc.contributor.author | Han, Hye-Suk | - |
dc.contributor.author | Leem, Dae-Ho | - |
dc.contributor.author | Choi, In-Sun | - |
dc.contributor.author | Jung, Ji-Youn | - |
dc.contributor.author | Kim, Hyeong-Jin | - |
dc.contributor.author | Moon, Kyung-Suk | - |
dc.contributor.author | Choi, Kyeong-Hee | - |
dc.contributor.author | Soh, Yunjo | - |
dc.contributor.author | Kong, Gu | - |
dc.contributor.author | Cho, Sung-Dae | - |
dc.contributor.author | Choi, Seoung Hwan | - |
dc.date.accessioned | 2022-12-20T21:23:55Z | - |
dc.date.available | 2022-12-20T21:23:55Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 1368-8375 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176391 | - |
dc.description.abstract | In this study, we found that oral squamous cell carcinomas (OSCCs) in Korean patients have a high level of COX-2 expression when compared with normal mucosa. Sulforaphane (SFN), rich in cruciferous vegetables, has been reported to display anti-cancer activity against many cancers. However, the effect and molecular mechanism of SFN in the proliferation of OSCC still remains unclear. To elucidate this mechanism, we investigated the anti-proliferative effect of SFN on KB and YD-10B cells and demonstrated that SFN significantly induced caspase-dependent apoptosis. Also, we observed that SFN inhibited COX-2 but not COX-1. In addition, bcl-2 protein, one of downstream targets of COX-2, was down-regulated by SFN. Furthermore, SFN also inhibited tumor growth in KB cell xenografts. These results show that SFN can act as a potent anti-oral cancer compound by inhibiting COX-2 activity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kong, Gu | - |
dc.identifier.doi | 10.1016/j.oraloncology.2008.07.003 | - |
dc.identifier.scopusid | 2-s2.0-67650401078 | - |
dc.identifier.wosid | 000268112800002 | - |
dc.identifier.bibliographicCitation | ORAL ONCOLOGY, v.45, no.8, pp.654 - 660 | - |
dc.relation.isPartOf | ORAL ONCOLOGY | - |
dc.citation.title | ORAL ONCOLOGY | - |
dc.citation.volume | 45 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 654 | - |
dc.citation.endPage | 660 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Dentistry, Oral Surgery & Medicine | - |
dc.subject.keywordPlus | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject.keywordPlus | PROSTATE-CANCER CELLS | - |
dc.subject.keywordPlus | MEDIATED APOPTOSIS | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | CYCLE ARREST | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | NECK-CANCER | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | HEAD | - |
dc.subject.keywordPlus | ISOTHIOCYANATE | - |
dc.subject.keywordAuthor | Human oral squamous cell carcinoma | - |
dc.subject.keywordAuthor | Sulforaphane | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | bcl-2 | - |
dc.subject.keywordAuthor | Xenograft | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1368837508002157?via%3Dihub | - |
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