Dietary Vitamin E and Quercetin Modulate Inflammatory Responses of Collagen-Induced Arthritis in Mice
DC Field | Value | Language |
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dc.contributor.author | Choi, Eun-Jin | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Yu, Rina | - |
dc.contributor.author | Youn, Jeehee | - |
dc.contributor.author | Sung, Mi-Kyung | - |
dc.date.accessioned | 2022-12-20T21:24:40Z | - |
dc.date.available | 2022-12-20T21:24:40Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176398 | - |
dc.description.abstract | Rheumatoid arthritis (RA) is characterized by chronic inflammation of the synovial joints. This study investigated whether or not a diet deficient in vitamin E is a possible risk factor in the development of RA and evaluated the efficacy of antioxidant supplementation. Male DBA/1J mice were maintained on either a control diet (C) or a vitamin E-depleted (-VE) diet for 4 weeks before arthritis induction. The mice in the control group were subdivided into the control group (C/C), the 0.05% alpha-tocopherol-supplemented group (C/+VE), and the 0.5% quercetin-supplemented group (C/+Q). The vitamin E-depleted group was subdivided into the -VE group (-VE/-VE), the 0.05% alpha-tocopherol-supplemented group (-VE/+VE), and the 0.5% quercetin-supplemented group (-VE/+Q) (in total, six groups, 27 mice per group). The mice were maintained on the experimental diets for 9 weeks. Study results indicate that the -VE/-VE group showed higher joint tissue tumor necrosis factor-alpha and interleukin-1 beta mRNA expressions, whereas alpha-tocopherol or quercetin supplementation reduced tissue cytokine mRNA levels to values comparable to those of the C/C group. The mice fed the -VE/-VE diet exhibited higher levels of circulating macrophage chemoattractant protein 1, nitric oxide, and prostaglandin E-2 compared to those in other groups. Supplementation with alpha-tocopherol or quercetin in mice fed -VE diet decreased these markers similar to those of the mice in the C/C group. No supplementation effect was observed, however, in the mice fed with the control diet prior to RA induction. These results suggest that dietary deficiency of vitamin E increases inflammatory responses and that antioxidants successfully suppress the inflammatory responses. However, significant clinical improvement may require longer observation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.title | Dietary Vitamin E and Quercetin Modulate Inflammatory Responses of Collagen-Induced Arthritis in Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Youn, Jeehee | - |
dc.identifier.doi | 10.1089/jmf.2008.1246 | - |
dc.identifier.scopusid | 2-s2.0-70149110651 | - |
dc.identifier.wosid | 000269569500010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.12, no.4, pp.770 - 775 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 770 | - |
dc.citation.endPage | 775 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001375426 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | ALPHA-TOCOPHEROL | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | INTERLEUKIN-1-BETA | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | ROS | - |
dc.subject.keywordAuthor | antioxidants | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | quercetin | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | vitamin E | - |
dc.identifier.url | https://www.liebertpub.com/doi/10.1089/jmf.2008.1246 | - |
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