Bacillus subtilis-specific poly-gamma-glutamic acid regulates development pathways of naive CD4(+) T cells through antigen-presenting cell-dependent and -independent mechanisms
DC Field | Value | Language |
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dc.contributor.author | Kim, Sunghoon | - |
dc.contributor.author | Yang, Jun Young | - |
dc.contributor.author | Lee, Kyuheon | - |
dc.contributor.author | Oh, Kyu Heon | - |
dc.contributor.author | Gi, Mia | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Paik, Doo Jin | - |
dc.contributor.author | Hong, Seokmann | - |
dc.contributor.author | Youn, Jeehee | - |
dc.date.accessioned | 2022-12-20T21:26:00Z | - |
dc.date.available | 2022-12-20T21:26:00Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 0953-8178 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176411 | - |
dc.description.abstract | Peripheral naive CD4(+) T cells selectively differentiate to type 1 T-h, type 2 T-h and IL-17-producing T-h (T(h)17) cells, depending on the priming conditions. Since these subsets develop antagonistically to each other to elicit subset-specific adaptive immune responses, balance between these subsets can regulate the susceptibility to diverse immune diseases. The present study was undertaken to determine whether poly-gamma-glutamic acid (gamma-PGA), an edible and safe exopolymer that is generated by microorganisms such as Bacillus subtilis, could modulate the development pathways of T-h subsets. The presence of gamma-PGA during priming promoted the development of T(h)1 and T(h)17 cells but inhibited development of T(h)2 cells. gamma-PGA up-regulated the expression of T-bet and ROR-gamma t, the master genes of T(h)1 and T(h)17 cells, respectively, whereas down-regulating the level of GATA-3, the master gene of T(h)2 cells. gamma-PGA induced the expression of IL-12p40, CD80 and CD86 in dendritic cells (DC) and macrophages in a Toll-like receptor-4-dependent manner, and the effect of gamma-PGA on T(h)1/T(h)2 development was dependent on the presence of antigen-presenting cells (APC). Furthermore, gamma-PGA-stimulated DC favored the polarization of naive CD4(+) T cells toward T(h)1 cells rather than T(h)2 cells. In contrast, gamma-PGA affected T(h)17 cell development, regardless of the presence or absence of APC. Thus, these data demonstrate that gamma-PGA has the potential to regulate the development pathways of naive CD4(+) T cells through APC-dependent and -independent mechanisms and to be applicable to treating T(h)2-dominated diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Bacillus subtilis-specific poly-gamma-glutamic acid regulates development pathways of naive CD4(+) T cells through antigen-presenting cell-dependent and -independent mechanisms | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.contributor.affiliatedAuthor | Paik, Doo Jin | - |
dc.contributor.affiliatedAuthor | Youn, Jeehee | - |
dc.identifier.doi | 10.1093/intimm/dxp065 | - |
dc.identifier.scopusid | 2-s2.0-70349486977 | - |
dc.identifier.wosid | 000268586900009 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOLOGY, v.21, no.8, pp.977 - 990 | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOLOGY | - |
dc.citation.title | INTERNATIONAL IMMUNOLOGY | - |
dc.citation.volume | 21 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 977 | - |
dc.citation.endPage | 990 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | MOUSE PERITONEAL-MACROPHAGES | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | OLIGODEOXYNUCLEOTIDES | - |
dc.subject.keywordPlus | INTERLEUKIN-12 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordAuthor | antigen-presenting cells | - |
dc.subject.keywordAuthor | Bacillus subtilis | - |
dc.subject.keywordAuthor | poly-gamma-glutamic acid | - |
dc.subject.keywordAuthor | T-h | - |
dc.identifier.url | https://academic.oup.com/intimm/article/21/8/977/694213 | - |
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