Autophagy genes mediate the effect of calcineurin on life span in C. elegans
DC Field | Value | Language |
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dc.contributor.author | Dwivedi, Meenakshi | - |
dc.contributor.author | Song, Hyun-Ok | - |
dc.contributor.author | Ahnn, Joohong | - |
dc.date.accessioned | 2022-12-20T21:43:52Z | - |
dc.date.available | 2022-12-20T21:43:52Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-07 | - |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176570 | - |
dc.description.abstract | Calcineurin (CaN) is a serine/threonine phosphatase, activated by Ca2+/calmodulin (Ca2+/CaM). CaN is known to regulate various cellular responses in different organisms. A recent study showed an extended life span in the calcineurin mutants of C elegans. In this study, we report that calcineurin defective strains exhibit enhanced autophagy. In addition, we found two essential autophagy genes (bec-1 and atg-7) are required for the life-span extension in calcineurin null mutants [cnb-1(jh103)]. Thus, for the first time we suggest that autophagy genes are required for the life-span regulation in calcineurin defective C. elegans strains. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.title | Autophagy genes mediate the effect of calcineurin on life span in C. elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahnn, Joohong | - |
dc.identifier.doi | 10.4161/auto.5.5.8157 | - |
dc.identifier.scopusid | 2-s2.0-67650243271 | - |
dc.identifier.wosid | 000268205300003 | - |
dc.identifier.bibliographicCitation | AUTOPHAGY, v.5, no.5, pp.604 - 607 | - |
dc.relation.isPartOf | AUTOPHAGY | - |
dc.citation.title | AUTOPHAGY | - |
dc.citation.volume | 5 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 604 | - |
dc.citation.endPage | 607 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | DEPENDENT PROTEIN PHOSPHATASE | - |
dc.subject.keywordPlus | CALMODULIN | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordAuthor | calcineurin | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | life span | - |
dc.subject.keywordAuthor | beclin 1 | - |
dc.subject.keywordAuthor | Atg-7 | - |
dc.subject.keywordAuthor | GFP::LGG-1 expression | - |
dc.identifier.url | https://www.tandfonline.com/doi/abs/10.4161/auto.5.5.8157 | - |
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