Discovery of Novel and Potent Cdc25 Phosphatase Inhibitors Based on the Structure-Based De Novo Design
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Hwangseo | - |
dc.contributor.author | Jung, Suk-Kyeong | - |
dc.contributor.author | Bahn, Young Jae | - |
dc.contributor.author | Jeong, Dae Gwin | - |
dc.contributor.author | Ryu, Seong Eon | - |
dc.contributor.author | Kim, Seung Jun | - |
dc.date.accessioned | 2022-12-20T22:03:38Z | - |
dc.date.available | 2022-12-20T22:03:38Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-06 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176742 | - |
dc.description.abstract | Cdc25 phosphatases have been considered as attractive drug targets for anticancer therapy due to the correlation of their overexpression with a wide variety of cancers. We have been able to identify five novel Cdc25 phosphatase inhibitors with micromolar activity by means of a structure-based de novo design method with a known inhibitor scaffold. Because the newly discovered inhibitors are structurally diverse and have desirable physicochemical properties as a drug candidate, they deserve further investigation as anticancer drugs. The differences in binding modes of the identified inhibitors in the active sites of Cdc25A and B are addressed in detail. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Discovery of Novel and Potent Cdc25 Phosphatase Inhibitors Based on the Structure-Based De Novo Design | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Seong Eon | - |
dc.identifier.doi | 10.5012/bkcs.2009.30.6.1313 | - |
dc.identifier.scopusid | 2-s2.0-69249193615 | - |
dc.identifier.wosid | 000267472400017 | - |
dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.30, no.6, pp.1313 - 1316 | - |
dc.relation.isPartOf | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.volume | 30 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1313 | - |
dc.citation.endPage | 1316 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001524407 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | BIOLOGICAL EVALUATION | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | SPECIFICITY | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | SOLVATION | - |
dc.subject.keywordPlus | DOCKING | - |
dc.subject.keywordAuthor | Cdc25 phosphatase | - |
dc.subject.keywordAuthor | De novo design | - |
dc.subject.keywordAuthor | Inhibitor | - |
dc.subject.keywordAuthor | Anticancer agents | - |
dc.identifier.url | http://koreascience.or.kr/article/JAKO200902727453636.page | - |
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