Orphan nuclear receptor Nurr1 induces neuron differentiation from embryonic cortical precursor cells via an extrinsic paracrine mechanism
- Authors
- Bae, Eun-Ji; Lee, Hyun-Seob; Park, Chang-Hwan; Lee, Sang-Hun
- Issue Date
- May-2009
- Publisher
- WILEY
- Keywords
- Nurr1; Paracrine; Neurogenesis; Neural precursor (NP) cell; Differentiation
- Citation
- FEBS LETTERS, v.583, no.9, pp.1505 - 1510
- Indexed
- SCIE
SCOPUS
- Journal Title
- FEBS LETTERS
- Volume
- 583
- Number
- 9
- Start Page
- 1505
- End Page
- 1510
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176871
- DOI
- 10.1016/j.febslet.2009.04.004
- ISSN
- 0014-5793
- Abstract
- Nurr1 is an orphan nuclear receptor-type transcription factor (TF) that plays critical roles in midbrain dopamine neuron development. This study demonstrated a novel role for Nurr1 in neuronal/astrocytic differentiation of neural precursor (NP) cells isolated from rat embryonic cortices: overexpression of this TF promoted NP cell differentiation towards neurons at the expense of astrocytic differentiation. Single cell-based lineage analyses and experiments using co-cultures revealed that Nurr1 elicited its neurogenic role in an extrinsic paracrine manner. We defined diffusible factors and downstream neurogenic TFs responsible for the Nurr1-mediated neuronal differentiation. (C) 2009 Federation of European Biochemical Societies.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 생화학·분자생물학교실 > 1. Journal Articles
- 서울 의생명공학전문대학원 > 서울 의생명과학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.