Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Choi, Dongho | - |
dc.contributor.author | Lee, Hyo Won | - |
dc.contributor.author | Hur, Kyung Yul | - |
dc.contributor.author | Kim, Jae Loon | - |
dc.contributor.author | Park, Gyeong-Sin | - |
dc.contributor.author | Jang, Si-Hyong | - |
dc.contributor.author | Song, Young Soo | - |
dc.contributor.author | Lang, Ki-Seok | - |
dc.contributor.author | Paik, Seung Sam | - |
dc.date.accessioned | 2022-12-20T22:27:34Z | - |
dc.date.available | 2022-12-20T22:27:34Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176875 | - |
dc.description.abstract | AIM: To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon cancer. METHODS: Immunohistochemistry for CD133, CD24 and CD44 was performed on the tissue microarray of 523 colorectal adenocarcinomas. Medical records were reviewed and clinicopathological analysis was performed. RESULTS: In colorectal adenocarcinoma, 128 of 523 cases (24.5%) were positive and 395 cases (75.5%) were negative for CD133 expression. Two hundred and sixty-four of 523 cases (50.5%) were positive and 259 cases (49.5%) were negative for CD24 expression. Five hundred and two of 523 cases (96%) were negative and 21 cases (4%) were positive for CD44 expression. Upon clinicopathological analysis, CD133 expression was present more in male patients (P = 0.002) and in advanced T stage cancer (P = 0.024). Correlation between CD24 expression and clinicopathological factors was seen in the degree of differentiation (P = 0.006). Correlation between CD44 expression and clinicopathological factors was seen in the tumor size (P = 0.001). Survival was not significantly related to CD133, CD24 and CD44 expression. CONCLUSION: CD markers were related to invasiveness and differentiation of colorectal adenocarcinoma. However, CD expression was not closely related to survival. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.title | Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Paik, Seung Sam | - |
dc.identifier.doi | 10.3748/wjg.15.2258 | - |
dc.identifier.scopusid | 2-s2.0-67650138937 | - |
dc.identifier.wosid | 000266200500012 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, v.15, no.18, pp.2258 - 2264 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 15 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 2258 | - |
dc.citation.endPage | 2264 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | MOLECULE | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | TISSUES | - |
dc.subject.keywordPlus | BREAST | - |
dc.subject.keywordPlus | LINES | - |
dc.subject.keywordAuthor | CD133 | - |
dc.subject.keywordAuthor | CD24 | - |
dc.subject.keywordAuthor | CD44 | - |
dc.subject.keywordAuthor | Colon cancer stem cells | - |
dc.subject.keywordAuthor | Colorectal adenocarcinoma | - |
dc.identifier.url | https://www.wjgnet.com/1007-9327/full/v15/i18/2258.htm | - |
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