Skin-Specific CD301b+ Dermal Dendritic Cells Drive IL-17−Mediated Psoriasis-Like Immune Response in Mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae-Gyun | - |
dc.contributor.author | Kim, Sung Hee | - |
dc.contributor.author | Park, Jeyun | - |
dc.contributor.author | Choi, Wanho | - |
dc.contributor.author | Sohn, Moah | - |
dc.contributor.author | Na, Hye Young | - |
dc.contributor.author | Lee, Minseok | - |
dc.contributor.author | Lee, Jae Won | - |
dc.contributor.author | Kim, Soo Min | - |
dc.contributor.author | Kim, Do-Young | - |
dc.contributor.author | Kim, Hyoung-Pyo | - |
dc.contributor.author | Choi, Jae-Hoon | - |
dc.contributor.author | Park, Chae Gyu | - |
dc.contributor.author | Lee, Min-Geol | - |
dc.date.accessioned | 2021-08-02T13:51:50Z | - |
dc.date.available | 2021-08-02T13:51:50Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/17702 | - |
dc.description.abstract | Conventional dendritic cells (cDCs) are composed of heterogeneous subsets commonly arising from dendritic cell (DC)-committed progenitors. A population of CD301b-expressing DCs has recently been identified in non lymphoid barrier tissues such as skin. However, whether CD3011D(+) DCs in the skin represent an ontogenetically unique subpopulation of migratory cDCs has not been fully addressed. Here, we demonstrated that CD3011D(+) dermal DCs were distinct subpopulation of FMS-like tyrosine kinase 3 ligand (FLT3L) dependent CD111D(+) cDC2 lineage, which required an additional GM-CSF cue for the adequate development. Although the majority of lymphoid-resident cDC2 lacked CD301b expression, dermal migratory cDC2 contained a substantial fraction of CD3011D(+) subset. Similar to CD301b- population, CD3011D(+) dermal DC development was closely regulated by FLT3 signaling, suggesting their common origin from FLT3L-responsive cDC progenitors. However, FLT3L-driven cDC progenitor culture was not sufficient, but additional GM-CSF treatment was required to produce CD3011D(+) cDC2. In vivo development of CD3011D(+) cDC2 was significantly augmented by exogenous GM-CSF, while the repopulation of CD3011D(+) dermal cDC2 was abrogated by GM-CSF neutralization. Functionally, CD3011D(+) cDC2 was capable of producing a high level of IL-23, and the depletion of CD3011D(+) cDC2 effectively prevented IL-17 mediated psoriasiform dermatitis. Therefore, our findings highlight the differentiation program of a distinct CD3011D(+) dermal cDC2 subset in the skin and its involvement in psoriatic inflammation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Skin-Specific CD301b+ Dermal Dendritic Cells Drive IL-17−Mediated Psoriasis-Like Immune Response in Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jae-Hoon | - |
dc.identifier.doi | 10.1016/j.jid.2017.11.003 | - |
dc.identifier.scopusid | 2-s2.0-85044152514 | - |
dc.identifier.wosid | 000428135400022 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INVESTIGATIVE DERMATOLOGY, v.138, no.4, pp.844 - 853 | - |
dc.relation.isPartOf | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.citation.title | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.citation.volume | 138 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 844 | - |
dc.citation.endPage | 853 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | BONE-MARROW CULTURES | - |
dc.subject.keywordPlus | DELTA T-CELLS | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | HIGH-DIMENSIONAL ANALYSIS | - |
dc.subject.keywordPlus | LANGERHANS CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | GM-CSF | - |
dc.subject.keywordPlus | PLAQUE-FORMATION | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0022202X17331524?via%3Dihub | - |
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