Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

A Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4(+)CD25(-) T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice

Full metadata record
DC Field Value Language
dc.contributor.authorJang, Eunkyeong-
dc.contributor.authorCho, Sin-Hye-
dc.contributor.authorPark, Hyunjoo-
dc.contributor.authorPaik, Doo-Jin-
dc.contributor.authorKim, Jung Mogg-
dc.contributor.authorYoun, Jeehee-
dc.date.accessioned2022-12-20T22:50:14Z-
dc.date.available2022-12-20T22:50:14Z-
dc.date.created2022-08-26-
dc.date.issued2009-04-
dc.identifier.issn0022-1767-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177033-
dc.description.abstractRheumatoid arthritis is a joint-specific autoimmune inflammatory disease of unknown etiology. The K/BxN mouse is a model of rheumatoid arthritis that is thought to be mainly due to autoantibody-mediated inflammatory responses. We showed previously that homeostatic proliferation of autoreactive CD4(+) T cells is required for disease initiation in-the K/BxN mice. In this study, we show that the homeostatically proliferating CD4(+)CD25(-) T cells produce IL-21. We generated IL-21R-deficient (IL-21R(-/-)) K/BxN mice and found that these mice were completely refractory to the development of spontaneous arthritis. They contained fewer CD4(+) T cells with a reduced proportion of homeostatically proliferating cells, fewer follicular Th cells, and, surprisingly, more Th17 cells than their control counterparts. They also failed to develop IgG1(+) memory B cells and autoantigen-specific IgG1 Ab-secreting cells. IL-21 induced expression of receptor activator of NF-kappa B ligand (RANKL) a regulator of osteoclastogenesis, and few RANKL-expressing infiltrates were found in the synovia of IL-21R(-/-) K/BxN mice. Thus, our results demonstrate that IL-21 forms a positive feedback autocrine loop involving homeostatically activated CD4(+) cells and that it plays an essential role in the development of autoimmune arthritis by mechanisms dependent on follicular Th cell development, autoreactive B cell maturation, and RANKL induction but independent of Th17 cell function. Consistent with this, in vivo administration of soluble the IL-21R-Fc fusion protein delayed the onset and progression of arthritis. Our findings suggest that effective targeting of IL-21-mediated processes may be useful in treating autoimmune arthritis.-
dc.language영어-
dc.language.isoen-
dc.publisherAMER ASSOC IMMUNOLOGISTS-
dc.titleA Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4(+)CD25(-) T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice-
dc.typeArticle-
dc.contributor.affiliatedAuthorPaik, Doo-Jin-
dc.contributor.affiliatedAuthorKim, Jung Mogg-
dc.contributor.affiliatedAuthorYoun, Jeehee-
dc.identifier.doi10.4049/jimmunol.0804350-
dc.identifier.scopusid2-s2.0-65249180981-
dc.identifier.wosid000265004700023-
dc.identifier.bibliographicCitationJOURNAL OF IMMUNOLOGY, v.182, no.8, pp.4649 - 4656-
dc.relation.isPartOfJOURNAL OF IMMUNOLOGY-
dc.citation.titleJOURNAL OF IMMUNOLOGY-
dc.citation.volume182-
dc.citation.number8-
dc.citation.startPage4649-
dc.citation.endPage4656-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.subject.keywordPlusFOLLICULAR-HELPER-CELLS-
dc.subject.keywordPlusSELF-REACTIVITY-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusGENERATION-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusINTERLEUKIN-21-
dc.subject.keywordPlusOSTEOCLASTOGENESIS-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusACTIVATION-
dc.identifier.urlhttps://www.jimmunol.org/content/182/8/4649-
Files in This Item
Go to Link
Appears in
Collections
서울 의과대학 > 서울 해부·세포생물학교실 > 1. Journal Articles
서울 의과대학 > 서울 미생물학교실 > 1. Journal Articles
서울 의과대학 > 서울 의학교육학교실 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Youn, Jee hee photo

Youn, Jee hee
COLLEGE OF MEDICINE (DEPARTMENT OF ANATOMY AND CELL BIOLOGY)
Read more

Altmetrics

Total Views & Downloads

BROWSE