뇌 성상세포종 환자의 외부 방사선치료
DC Field | Value | Language |
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dc.contributor.author | Chun, Ha Chung | - |
dc.date.accessioned | 2022-12-20T22:55:12Z | - |
dc.date.available | 2022-12-20T22:55:12Z | - |
dc.date.created | 2022-09-19 | - |
dc.date.issued | 2009-03 | - |
dc.identifier.issn | 1229-8719 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177088 | - |
dc.description.abstract | PURPOSE:This study was designed to evaluate the effectiveness of postoperative radiotherapy for patients with low-grade astrocytomas and to define an optimal radiotherapeutic regimen and prognostic factors. MATERIALS AND METHODS: A total of 69 patients with low-grade astrocytomas underwent surgery and postoperative radiotherapy immediately following surgery at our institution between October 1989 and September 2006. The median patient age was 36 years. Forty-one patients were 40 years or younger and 28 patients were 41 years or older. Fourteen patients underwent a biopsy alone and the remaining 55 patients underwent a subtotal resection. Thirty-nine patients had a Karnofsky performance status of less than 80% and 30 patients had a Karnofsky performance status greater than 80%. Two patients were treated with whole brain irradiation followed by a coned down boost field to the localized area. The remaining 67 patients were treated with a localized field with an appropriate margin. Most of the patients received a dose of 50~55 Gy and majority of the patients were treated with a dose of 54 Gy. RESULTS: The overall 5-year and 7-year survival rates for all of the 69 patients were 49% and 44%, respectively. Corresponding disease free survival rates were 45% and 40%, respectively. Patients who underwent a subtotal resection showed better survival than patients who underwent a biopsy alone. The overall 5-year survival rates for patients who underwent a subtotal resection and patients who underwent a biopsy alone were 57% and 38%, respectively (p<0.05). Forty-one patients who were 40 years or younger showed a better overall 5-year survival rate as compared with 28 patients who were 41 years or older (56% versus 40%, p<0.05). The overall 5-year survival rates for 30 patients with a Karnofsky performance status greater than 80% and 39 patients with a Karnofsky performance status less than 80% were 51% and 47%, respectively. This finding was not statistically significant. Although one patient was not able to complete the treatment because of neurological deterioration, there were no significant treatment related toxicities. CONCLUSION: Postoperative radiotherapy following surgery is a safe and effective treatment for patients with low-grade astrocytomas. The extent of surgery and age were noted as significant prognostic factors in this study. However, further effective treatment might be necessary in the future to improve long-term survival rates. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한방사선종양학회 | - |
dc.title | 뇌 성상세포종 환자의 외부 방사선치료 | - |
dc.title.alternative | External Beam Radiotherapy in the Management of Low Grade Astrocytoma of the Brain | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chun, Ha Chung | - |
dc.identifier.doi | 10.3857/jkstro.2009.27.1.23 | - |
dc.identifier.bibliographicCitation | Radiation oncology journal, v.27, no.1, pp.23 - 28 | - |
dc.relation.isPartOf | Radiation oncology journal | - |
dc.citation.title | Radiation oncology journal | - |
dc.citation.volume | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 23 | - |
dc.citation.endPage | 28 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001332299 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Radiotherapy | - |
dc.subject.keywordAuthor | Low-grade astrocytoma | - |
dc.subject.keywordAuthor | 방사선 치료 | - |
dc.subject.keywordAuthor | 뇌 성상세포종 | - |
dc.identifier.url | https://www.e-roj.org/journal/view.php?doi=10.3857/jkstro.2009.27.1.23 | - |
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