The gep oncogenes, G alpha(12) and G alpha(13), upregulate the transforming growth factor-beta 1 gene
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung Joong | - |
dc.contributor.author | Yang, Jin Won | - |
dc.contributor.author | Cho, Il-Je | - |
dc.contributor.author | Kim, Wondong | - |
dc.contributor.author | Cho, Min Kyung | - |
dc.contributor.author | Lee, Chang Ho | - |
dc.contributor.author | Kim, Sang Geon | - |
dc.date.accessioned | 2022-12-20T23:13:03Z | - |
dc.date.available | 2022-12-20T23:13:03Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-03 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177192 | - |
dc.description.abstract | Transforming growth factor-beta 1 (TGF beta 1) plays a role in neoplastic transformation and transdifferentiation. G alpha(12) and G alpha(13), referred to as the gep oncogenes, stimulate mitogenic pathways. Nonetheless, no information is available regarding their roles in the regulation of the TGF beta 1 gene and the molecules linking them to gene transcription. Knockdown or knockout experiments using murine embryonic fibroblasts and hepatic stellate cells indicated that a G alpha(12) and G alpha(13) deficiency reduced constitutive, auto-stimulatory or thrombin-inducible TGF beta 1 gene expression. In contrast, transfection of activated mutants of G alpha(12) and G alpha(13) enabled the knockout cells to promote TGF beta 1 induction. A promoter deletion analysis suggested that activating protein 1 (AP-1) plays a role in TGF beta 1 gene transactivation, which was corroborated by the observation that a deficiency of the G-proteins decreased the AP-1 activity, whereas their activation enhanced it. Moreover, mutation of the AP-1-binding site abrogated the ability of G alpha(12) and G alpha(13) to induce the TGF beta 1 gene. Transfection of a dominant-negative mutant of Rho or Rac, but not Cdc42, prevented gene transactivation and decreased AP-1 activity downstream of G alpha 12 and G alpha 13. In summary, G alpha 12 and G alpha 13 regulate the expression of the TGF beta 1 gene through an increase in Rho/Rac-dependent AP-1 activity, implying that the G-protein-coupled receptor (GPCR)-G alpha(12) pathway is involved in the TGF beta 1-mediated transdifferentiation process. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGERNATURE | - |
dc.title | The gep oncogenes, G alpha(12) and G alpha(13), upregulate the transforming growth factor-beta 1 gene | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Chang Ho | - |
dc.identifier.doi | 10.1038/onc.2008.488 | - |
dc.identifier.scopusid | 2-s2.0-62049085214 | - |
dc.identifier.wosid | 000263906200007 | - |
dc.identifier.bibliographicCitation | ONCOGENE, v.28, no.9, pp.1230 - 1240 | - |
dc.relation.isPartOf | ONCOGENE | - |
dc.citation.title | ONCOGENE | - |
dc.citation.volume | 28 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1230 | - |
dc.citation.endPage | 1240 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | HEPATIC STELLATE CELLS | - |
dc.subject.keywordPlus | KAPPA-B-ALPHA | - |
dc.subject.keywordPlus | LIVER FIBROSIS | - |
dc.subject.keywordPlus | G-PROTEINS | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | PROMOTER REGION | - |
dc.subject.keywordPlus | CIRRHOTIC LIVER | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordAuthor | G alpha(12) members | - |
dc.subject.keywordAuthor | transforming growth factor-beta 1 | - |
dc.subject.keywordAuthor | hepatic stellate cell | - |
dc.subject.keywordAuthor | activating protein 1 | - |
dc.identifier.url | https://www.nature.com/articles/onc2008488 | - |
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