Berberine Diminishes the Side Population and ABCG2 Transporter Expression in MCF-7 Breast Cancer Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jong Bin | - |
dc.contributor.author | Ko, Eunyoung | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Shin, Incheol | - |
dc.contributor.author | Park, Seo Young | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.date.accessioned | 2022-12-21T00:27:18Z | - |
dc.date.available | 2022-12-21T00:27:18Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2008-11 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177700 | - |
dc.description.abstract | The plant alkaloid berberine has many biological activities including the ability to induce cell cycle arrest and apoptosis, making it a potentially useful agent for targeting cancer cells. We have analyzed the effects of berberine oil MCF-7 breast cancer cells. Berberine was added to MCF-7 cells in Culture, and proliferation, side population (SP) cells and expression of ABCG2 were examined. Berberine caused a close-dependent reduction in Proliferation. Hoechst 33342 dye staining and FACS analysis revealed that berberine treatment caused a decrease in SP cells relative to untreated controls. In addition, berberine treatment was associated with a decrease in expression of ABCG2 relative to untreated controls. These results indicate that the growth inhibitory effects of berberine treatment on MCF-7 cells may be partly via effects oil SP and ABCG2 expression. Further work is warranted to explore whether berberine may be a novel therapeutic drug useful for targeting breast cancer stem cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.title | Berberine Diminishes the Side Population and ABCG2 Transporter Expression in MCF-7 Breast Cancer Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Incheol | - |
dc.identifier.doi | 10.1055/s-0028-1088313 | - |
dc.identifier.scopusid | 2-s2.0-57149096060 | - |
dc.identifier.wosid | 000261573500004 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.74, no.14, pp.1693 - 1700 | - |
dc.relation.isPartOf | PLANTA MEDICA | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 74 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 1693 | - |
dc.citation.endPage | 1700 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | INHIBITS GROWTH | - |
dc.subject.keywordPlus | CARCINOMA CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | HOECHST-33342 | - |
dc.subject.keywordPlus | BERBERRUBINE | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | berberine | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | cancer stem cells | - |
dc.subject.keywordAuthor | side population | - |
dc.subject.keywordAuthor | ABCG2 | - |
dc.identifier.url | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0028-1088313 | - |
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