Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
DC Field | Value | Language |
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dc.contributor.author | Kim, Do-Hyun | - |
dc.contributor.author | Park, Hong-Jai | - |
dc.contributor.author | Lim, Sangho | - |
dc.contributor.author | Koo, Ja-Hyun | - |
dc.contributor.author | Lee, Hong-Gyun | - |
dc.contributor.author | Choi, Jin Ouk | - |
dc.contributor.author | Oh, Ji Hoon | - |
dc.contributor.author | Ha, Sang-Jun | - |
dc.contributor.author | Kang, Min-Jong | - |
dc.contributor.author | Lee, Chang-Min | - |
dc.contributor.author | Lee, Chun Geun | - |
dc.contributor.author | Elias, Jack A. | - |
dc.contributor.author | Choi, Je-Min | - |
dc.date.accessioned | 2021-08-02T13:53:19Z | - |
dc.date.available | 2021-08-02T13:53:19Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/17812 | - |
dc.description.abstract | Chitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T cell and its clinical implications are largely unknown. Here we show that Chi3l1 expression was increased in activated T cells, especially in Th2 cells. In addition, Chi3l1-deficient T cells are hyper-responsive to TcR stimulation and are prone to differentiating into Th1 cells. Chi3l1-deficient Th1 cells show increased expression of anti-tumor immunity genes and decreased Th1 negative regulators. Deletion of Chi3l1 in T cells in mice show reduced melanoma lung metastasis with increased IFN gamma and TNF alpha-producing T cells in the lung. Furthermore, silencing of Chi3l1 expression in the lung using peptide-siRNA complex (dNP2-siChi3l1) efficiently inhibit lung metastasis with enhanced Th1 and CTL responses. Collectively, this study demonstrates Chi3l1 is a regulator of Th1 and CTL which could be a therapeutic target to enhance anti-tumor immunity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Je-Min | - |
dc.identifier.doi | 10.1038/s41467-017-02731-6 | - |
dc.identifier.scopusid | 2-s2.0-85041668451 | - |
dc.identifier.wosid | 000424092000005 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.9, no.1, pp.1 - 14 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 14 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | 3-LIKE 1 | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | NUCLEAR-LOCALIZATION | - |
dc.subject.keywordPlus | TUMOR ANGIOGENESIS | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | TISSUE RESPONSES | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | MYELOID CELLS | - |
dc.subject.keywordPlus | CATHEPSIN-E | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.identifier.url | https://www.nature.com/articles/s41467-017-02731-6 | - |
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