Development of electroactive and elastic nanofibers that contain polyaniline and poly(L-lactide-co-epsilon-caprolactone) for the control of cell adhesion
DC Field | Value | Language |
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dc.contributor.author | Jeong, Sung In | - |
dc.contributor.author | Jun, In Dong | - |
dc.contributor.author | Choi, Moon Jae | - |
dc.contributor.author | Nho, Young Chang | - |
dc.contributor.author | Lee, Young Moo | - |
dc.contributor.author | Shin, Heungsoo | - |
dc.date.accessioned | 2022-12-21T02:05:48Z | - |
dc.date.available | 2022-12-21T02:05:48Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2008-07 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178202 | - |
dc.description.abstract | In this work, electrically conductive polyaniline (PAni) doped with camphorsulfonic acid (CPSA) is blended with poly(L-lactide-co-epsilon-caprolactone) (PLCL), and then electrospun to prepare uniform nanofibers. The CPSA-PAni/PLCL nanofibers show a smooth fiber structure without coarse lumps or beads and consistent fiber diameters (which range from 100 to 700 nm) even with an increase in the amount of CPSA-PAni (from 0 to 30 wt.-%). However, the elongation at break decreases from 391.54 +/- 9.20% to 207.85 +/- 6.74% when 30% of CPSA-PAni is incorporated. Analysis of the surface of the nanofibers demonstrates the presence of homogeneously blended CPSA-PAni. Most importantly, a four-point probe analysis reveals that electrical properties are maintained in the nanofibers where the conductivity is significantly increased from 0.0015 to 0.0138 S . cm(-1) when the nanofibers are prepared with 30% CPSA-PAni. The cell adhesion tests using human dermal fibroblasts, NIH-3T3 fibroblasts, and C2C12 myoblasts demonstrate significantly higher adhesion on the CPSA-PAni/PLCL nanofibers than pure PLCL nanofibers. In addition, the growth of NIH-3T3 fibroblasts is enhanced under the stimulation of various direct current flows. The CPSA-PAni/PLCL nanofibers with electrically conductive properties may potentially be used as a platform substrate to study the effect of electrical signals on cell activities and to direct desirable cell function for tissue engineering applications. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Development of electroactive and elastic nanofibers that contain polyaniline and poly(L-lactide-co-epsilon-caprolactone) for the control of cell adhesion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Moo | - |
dc.contributor.affiliatedAuthor | Shin, Heungsoo | - |
dc.identifier.doi | 10.1002/mabi.200800005 | - |
dc.identifier.scopusid | 2-s2.0-54049115978 | - |
dc.identifier.wosid | 000257817300004 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, v.8, no.7, pp.627 - 637 | - |
dc.relation.isPartOf | MACROMOLECULAR BIOSCIENCE | - |
dc.citation.title | MACROMOLECULAR BIOSCIENCE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 627 | - |
dc.citation.endPage | 637 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | TISSUE ENGINEERING APPLICATIONS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ELECTRICAL-STIMULATION | - |
dc.subject.keywordPlus | GELATIN NANOFIBERS | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | STIFFNESS | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordAuthor | conducting polymers | - |
dc.subject.keywordAuthor | electrospinning | - |
dc.subject.keywordAuthor | nanofibers | - |
dc.subject.keywordAuthor | polyaniline | - |
dc.subject.keywordAuthor | poly(L-lactide-co-epsilon-caprolactone) | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/mabi.200800005 | - |
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