Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats
DC Field | Value | Language |
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dc.contributor.author | Park, Sang Woon | - |
dc.contributor.author | Oh, Tae Young | - |
dc.contributor.author | Kim, Yong Seok | - |
dc.contributor.author | Sim, Hyejin | - |
dc.contributor.author | Park, Sang Jong | - |
dc.contributor.author | Jang, Eun Jung | - |
dc.contributor.author | Park, Joo Sang | - |
dc.contributor.author | Baik, Hyun Wook | - |
dc.contributor.author | Hahm, Ki Baik | - |
dc.date.accessioned | 2022-12-21T02:51:44Z | - |
dc.date.available | 2022-12-21T02:51:44Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2008-06 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178563 | - |
dc.description.abstract | Background and Aim: Based on our previous studies that Artemisia asiatica extracts exert either antioxidative or cytoprotective actions against non-steroidal anti-inflammatory drugs or Helicobacter pylori-induced gastric mucosal injury, or imposes qualified ulcer healing in an acetic acid-induced gastric ulcer model, we investigated the protective effects of Artemisia asiatica extracts against ethanol-induced gastric mucosal injury. Methods: Sprague-Dawley rats received 4 g/kg body weight (BW) of absolute ethanol intragastrically, which produced visible hemorrhagic gastric lesions 60 min later. Results: In this animal setting, the pretreatment of Artemisia extracts (30 or 100 mg/kg BW), 1 h before ethanol administration, significantly attenuated the source of gastric injury, which was assessed with gross and microscopic analysis (P < 0.01). Protection from alcohol-induced damage with Artemisia pretreatment was associated with significantly decreased lipid peroxidation, protecting gastric mucosa from glutathione depletion, as well as the inhibition of the cytochrome 2E1 ethanol-metabolizing enzyme. It attenuated the expressions of ethanol-induced pro-inflammatory cytokines, including interleukin (IL)-1 beta and interferon-gamma, a weak activation of IL-10, the inhibition of the alcohol-induced overexpression of intercellular adhesion molecule-1, and the considerable induction of heat shock protein-72 expression in gastric mucosal homogenates. Conclusion: The data suggest that the ethanol extracts of Artemisia asiatica exerted significant protection from alcohol-induced gastric mucosal injury through bioregulation, which is essential for cytoprotection and anti-inflammation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong Seok | - |
dc.identifier.doi | 10.1111/j.1440-1746.2008.05333.x | - |
dc.identifier.scopusid | 2-s2.0-44949133340 | - |
dc.identifier.wosid | 000256540200027 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.23, no.6, pp.976 - 984 | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.title | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 976 | - |
dc.citation.endPage | 984 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | ALCOHOL-CONSUMPTION | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DA-9601 | - |
dc.subject.keywordPlus | WOGONIN | - |
dc.subject.keywordPlus | IL-10 | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Artemisia asiatica | - |
dc.subject.keywordAuthor | DA-9601 | - |
dc.subject.keywordAuthor | ethanol | - |
dc.subject.keywordAuthor | gastric injury | - |
dc.subject.keywordAuthor | glutathione | - |
dc.subject.keywordAuthor | lipid peroxide | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2008.05333.x | - |
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