Abnormal cortical neural synchrony during working memory in schizophrenia
DC Field | Value | Language |
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dc.contributor.author | Kang, Seung Suk | - |
dc.contributor.author | MacDonald, Angus W., III | - |
dc.contributor.author | Chafee, Matthew V. | - |
dc.contributor.author | Im, Chang-Hwan | - |
dc.contributor.author | Bernat, Edward M. | - |
dc.contributor.author | Davenport, Nicholas D. | - |
dc.contributor.author | Sponheim, Scott R. | - |
dc.date.accessioned | 2021-08-02T13:53:50Z | - |
dc.date.available | 2021-08-02T13:53:50Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1388-2457 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/17863 | - |
dc.description.abstract | Objective: To better understand the origins of working memory (WM) impairment in schizophrenia we investigated cortical oscillatory activity in people with schizophrenia (PSZ) while they performed a WM task requiring encoding, maintenance, and retrieval/manipulation processes of spatial information. Methods: We examined time-frequency synchronous energy of cortical source signals that were derived from magnetoencephalography (MEG) localized to cortical regions using WM-related hemodynamic responses and individualized structural head-models. Results: Compared to thirteen healthy controls (HC), twelve PSZ showed performance deficits regardless of WM-load or duration. During encoding, PSZ had early theta and delta event-related synchrony (ERS) deficits in prefrontal and visual cortices which worsened with greater memory load and predicted WM performance. During prolonged maintenance of material, PSZ showed deficient beta event-related desynchrony (ERD) in dorsolateral prefrontal, posterior parietal, and visual cortices. In retrieval, PSZ showed reduced delta/theta ERS in the anterior prefrontal and ventral visual cortices and diminished gamma ERS in the premotor and posterior parietal cortices. Conclusions: Although beta/gamma cortical neural oscillatory deficits for maintenance/retrieval are evident during WM, the abnormal prefrontal theta-frequency ERS for encoding is most predictive of poor WM in schizophrenia. Significance: Time-frequency-spatial analysis identified process-and frequency-specific neural synchrony abnormalities underlying WM deficits in schizophrenia. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Abnormal cortical neural synchrony during working memory in schizophrenia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Im, Chang-Hwan | - |
dc.identifier.doi | 10.1016/j.clinph.2017.10.024 | - |
dc.identifier.scopusid | 2-s2.0-85036574813 | - |
dc.identifier.wosid | 000418602000024 | - |
dc.identifier.bibliographicCitation | CLINICAL NEUROPHYSIOLOGY, v.129, no.1, pp.210 - 221 | - |
dc.relation.isPartOf | CLINICAL NEUROPHYSIOLOGY | - |
dc.citation.title | CLINICAL NEUROPHYSIOLOGY | - |
dc.citation.volume | 129 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 210 | - |
dc.citation.endPage | 221 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | INDEPENDENT COMPONENT ANALYSIS | - |
dc.subject.keywordPlus | CONSTRUCTIONAL APRAXIA | - |
dc.subject.keywordPlus | PARIETAL CORTEX | - |
dc.subject.keywordPlus | OSCILLATORY ACTIVITY | - |
dc.subject.keywordPlus | THETA OSCILLATIONS | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | POWER CHANGES | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | EEG | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | Schizophrenia | - |
dc.subject.keywordAuthor | Working memory | - |
dc.subject.keywordAuthor | Neural oscillation | - |
dc.subject.keywordAuthor | Cortical source analysis | - |
dc.subject.keywordAuthor | Magnetoencephalography (MEG) | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1388245717311197?via%3Dihub | - |
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