Identification of proteomic biomarkers of preeclampsia in amniotic fluid using SELDI-TOF mass spectrometry
DC Field | Value | Language |
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dc.contributor.author | Park, Joong Shin | - |
dc.contributor.author | Oh, Kyoung-Jin | - |
dc.contributor.author | Norwitz, Errol R. | - |
dc.contributor.author | Han, Joong-Soo | - |
dc.contributor.author | Chol, Hye-Jin | - |
dc.contributor.author | Seong, Hyo Suk | - |
dc.contributor.author | Kang, Yoon Dan | - |
dc.contributor.author | Park, Chan-Wook | - |
dc.contributor.author | Kim, Byoung Jae | - |
dc.contributor.author | Jun, Jong Kwan | - |
dc.contributor.author | Syn, Hee Chul | - |
dc.date.accessioned | 2022-12-21T03:07:35Z | - |
dc.date.available | 2022-12-21T03:07:35Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2008-05 | - |
dc.identifier.issn | 1933-7191 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178646 | - |
dc.description.abstract | Objective: To identify proteomic biomarkers in amniotic fluid (AF) that can distinguish preeclampsia (PE) from chronic hypertension (CHTN) and normotensive controls (CTR). Methods: AF from women with PE, CHTN, and CTR were subjected to proteomic analysis by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. Results: Proteomic profiling of AF identified 2 biomarkers: peak X (17399.11 Da), which distinguished PE from CTR, and peak Y (28023.34 Da), which distinguished PE and CHTN from CTR. High performance liquid chromatography fractions containing the biomarkers were subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis and in-gel tryptic digestion. The biomarkers were matched to proapolipoprotein A-I (peak Y) and a functionally obscure peptide, SBBI42 (peak X). Western blot analysis confirmed that AF from PE and CHTN had higher proapolipoprotein A-I levels than CTR. Conclusion: Proteomic analysis of AF can distinguish PE from CHTN and CTR. The discriminatory proteins were identified as proapolipoprotein A-I and SBB142. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.title | Identification of proteomic biomarkers of preeclampsia in amniotic fluid using SELDI-TOF mass spectrometry | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Joong-Soo | - |
dc.identifier.doi | 10.1177/1933719108316909 | - |
dc.identifier.scopusid | 2-s2.0-45149116563 | - |
dc.identifier.wosid | 000257086700006 | - |
dc.identifier.bibliographicCitation | REPRODUCTIVE SCIENCES, v.15, no.5, pp.457 - 468 | - |
dc.relation.isPartOf | REPRODUCTIVE SCIENCES | - |
dc.citation.title | REPRODUCTIVE SCIENCES | - |
dc.citation.volume | 15 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 457 | - |
dc.citation.endPage | 468 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalResearchArea | Reproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Reproductive Biology | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | PROAPOLIPOPROTEIN-A-I | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | FETOMATERNAL UNIT | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | LIPOPROTEIN | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordAuthor | preeclampsia | - |
dc.subject.keywordAuthor | amniotic fluid | - |
dc.subject.keywordAuthor | SELDI | - |
dc.subject.keywordAuthor | proapolipoprotein A-I | - |
dc.subject.keywordAuthor | SBBI42 | - |
dc.identifier.url | https://link.springer.com/article/10.1177/1933719108316909 | - |
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