CD4(+)CD25(+) regulatory T cells selectively diminish systemic autoreactivity in arthritic K/BxN mice
DC Field | Value | Language |
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dc.contributor.author | Kang, Sang Mee | - |
dc.contributor.author | Jang, Eunkyeong | - |
dc.contributor.author | Paik, Doo-Jin | - |
dc.contributor.author | Jang, Young-Ju | - |
dc.contributor.author | Youn, Jeehee | - |
dc.date.accessioned | 2022-12-21T04:42:34Z | - |
dc.date.available | 2022-12-21T04:42:34Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2008-02 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179042 | - |
dc.description.abstract | Although the arthritis symptoms observed in the K/BxN model have been shown to be dependent on the functions of T and B cells specific to the self antigen glucose-6-phosphate isomerase, less is known about the in vivo roles of CD4(+)CD25(+) regulatory T (T-reg) cells in the pathology of K/BxN mice. We determined the quantitative and functional characteristics of the T-reg cells in K/BxN mice. These mice contained a higher percentage of Foxp3(+) T-reg cells among the CD4(+) T cells than their BxN littermates. These T-reg cells were anergic and efficiently suppressed the proliferation of naive CD4(+) T cells and cytokine production by effector CD4(+) T cells in vitro. Antibody-mediated depletion of CD25(+) cells caused K/BxN mice to develop multi-organ inflammation and autoantibody production, while the symptoms of arthritis were not affected. These results demonstrate that despite the inability of the T-reg cells to suppress arthritis development, they play a critical role protecting the arthritic mice from systemic expansion of autoinimunity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | CD4(+)CD25(+) regulatory T cells selectively diminish systemic autoreactivity in arthritic K/BxN mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Paik, Doo-Jin | - |
dc.contributor.affiliatedAuthor | Youn, Jeehee | - |
dc.identifier.scopusid | 2-s2.0-42949127096 | - |
dc.identifier.wosid | 000253740600008 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.25, no.1, pp.64 - 69 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 64 | - |
dc.citation.endPage | 69 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001245422 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | EXPANSION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | autoimmunity | - |
dc.subject.keywordAuthor | K/BxN model | - |
dc.subject.keywordAuthor | regulatory T cells | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.identifier.url | https://www.molcells.org/journal/view.html?pn=search&uid=176&vmd=Full | - |
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