Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A
DC Field | Value | Language |
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dc.contributor.author | Lee, Jin Young | - |
dc.contributor.author | Park, Hye Ri | - |
dc.contributor.author | Oh, Yu Kyoung | - |
dc.contributor.author | Kim, Yeong Jeon | - |
dc.contributor.author | Youn, Jeehee | - |
dc.contributor.author | Han, Joong Soo | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.date.accessioned | 2022-12-21T05:13:14Z | - |
dc.date.available | 2022-12-21T05:13:14Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2007-12 | - |
dc.identifier.issn | 0946-2716 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179257 | - |
dc.description.abstract | Clostridium difficile toxin A causes acute colitis associated with intense infiltration of neutrophils. Although C. difficile toxin A is known to induce nuclear factor-kappaB-mediated chemokine expression in intestinal epithelial cells, little is known about its effect on the regulation of activator protein-1 (AP-1) by mitogen-activated protein kinase (MAPK). In the present study, we investigated whether the MAPK and AP-1 signaling pathway is involved in interleukin (IL)-8 expression and enteric inflammation in response to stimulation with toxin A. Toxin A activated MAPK and AP-1 composed of c-Jun/c-Fos heterodimers in primary intestinal epithelial cells and HT-29 cell lines. Transfection with mutant genes for Ras, c-Jun, p38, or c-Jun N-terminal kinase (JNK) significantly inhibited C. difficile toxin A-induced activation of AP-1 and expression of IL-8 in HT-29 cell lines. Furthermore, the p38 inhibitor SB203580 attenuated toxin A-induced inflammation in vivo in the mouse ileum, evidenced by a significant decrease in neutrophil infiltration, villous destruction, and mucosal congestion. Our results suggest that the Ras/MAPK cascade acts as the upstream signaling for AP-1 activation and IL-8 expression in toxin A-stimulated intestinal epithelial cells and may be involved in the development of enteritis after infection with toxin A-producing C. difficile. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Youn, Jeehee | - |
dc.contributor.affiliatedAuthor | Han, Joong Soo | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.identifier.doi | 10.1007/s00109-007-0237-7 | - |
dc.identifier.scopusid | 2-s2.0-36849012986 | - |
dc.identifier.wosid | 000251487500015 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR MEDICINE-JMM, v.85, no.12, pp.1393 - 1404 | - |
dc.relation.isPartOf | JOURNAL OF MOLECULAR MEDICINE-JMM | - |
dc.citation.title | JOURNAL OF MOLECULAR MEDICINE-JMM | - |
dc.citation.volume | 85 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1393 | - |
dc.citation.endPage | 1404 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INTESTINAL EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION PATHWAYS | - |
dc.subject.keywordPlus | C-JUN | - |
dc.subject.keywordPlus | INFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | CHEMOKINE EXPRESSION | - |
dc.subject.keywordPlus | KINASE ACTIVATION | - |
dc.subject.keywordPlus | MEK KINASE | - |
dc.subject.keywordPlus | RAS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | activator protein-1 | - |
dc.subject.keywordAuthor | Clostridium difficile toxin A | - |
dc.subject.keywordAuthor | interleukin-8 | - |
dc.subject.keywordAuthor | epithelial cells | - |
dc.subject.keywordAuthor | mitogen-activated protein kinase | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00109-007-0237-7 | - |
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