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Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy

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dc.contributor.authorMoon, Byung Seok-
dc.contributor.authorPark, Moon-Taek-
dc.contributor.authorPark, Jeong Hoon-
dc.contributor.authorKim, Sang Wook-
dc.contributor.authorLee, Kyo Chul-
dc.contributor.authorAn, Gwang Il-
dc.contributor.authorYang, Seung Dae-
dc.contributor.authorChi, Dae Yoon-
dc.contributor.authorCheon, Gi Jeong-
dc.contributor.authorLee, Su-Jae-
dc.date.accessioned2022-12-21T05:16:43Z-
dc.date.available2022-12-21T05:16:43Z-
dc.date.issued2007-12-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179290-
dc.description.abstractEight D-ribo-phytosphingosine derivatives were synthesized from D-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1 h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherPergamon Press Ltd.-
dc.titleSynthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2007.09.037-
dc.identifier.scopusid2-s2.0-35648950005-
dc.identifier.wosid000253489000048-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.17, no.23, pp 6643 - 6646-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume17-
dc.citation.number23-
dc.citation.startPage6643-
dc.citation.endPage6646-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusRESISTANT CANCER-CELLS-
dc.subject.keywordPlusCONCURRENT RADIATION-
dc.subject.keywordPlusIONIZING-RADIATION-
dc.subject.keywordPlusLUNG-CANCER-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusTAXOL-
dc.subject.keywordPlusCOMBINATION-
dc.subject.keywordPlusPACLITAXEL-
dc.subject.keywordPlusCERAMIDES-
dc.subject.keywordPlusRADIOTHERAPY-
dc.subject.keywordAuthorPhytoceramide-
dc.subject.keywordAuthorPhytosphingosine-
dc.subject.keywordAuthorRadiosensitizer-
dc.subject.keywordAuthorSphingolipids-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0960894X07010797?via%3Dihub-
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