난소의 경계성 및 악성 표면상피종양에서 c-erbB-2, EGFR, p53 발현 및 Ki-67 지수에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민경환 | - |
dc.contributor.author | 박문향 | - |
dc.date.accessioned | 2022-12-21T05:49:55Z | - |
dc.date.available | 2022-12-21T05:49:55Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2007-10 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179494 | - |
dc.description.abstract | Background : An ovarian surface epithelial tumor is a heterogenous disease, and various biological and molecular factors are important for its development and progression. Several findings support EGFR or c-erbB-2 as adverse prognostic indicators for an ovarian carcinoma. Methods : We reviewed the histological and clinical findings of 52 carcinomas (17 endometrioid, 16 serous, 13 mucinous and 6 clear cell tumors), and 26 borderline (10 serous and 16 mucinous) tumors. Expression of c-erbB-2, EGFR, p53, and Ki-67 was evaluated on paraffin-embedded tissue from a primary ovarian tumor by immunohistochemical methods. Results: Expression of c-erbB-2 was found in 7.6% of tumors and expression of EGFR was found in 9.6% of tumors by immunohistochemical analysis. No significance was found between cerbB-2 and EGFR expression as indicators of a poor prognosis. The expression of p53 and Ki-67 (>50%) correlated with the grade and type of tumor in the ovarian cancers. p53 and Ki-67 overexpression (>50%) was absent in the borderline ovarian tumors, whereas ovarian carcinomas showed expression of both p53 and Ki-67. Conclusion : Expression of c-erbB2, EGFR, p53, and Ki-67 as determined by immunohistochemical analysis did not correlate with prognostic significance. However, p53 and Ki-67 expression may be used as markers to predict aggressive behavior, and to differentiate between malignant and borderline epithelial ovarian tumors. Further large-scale studies are required to clarify the significance of c-erbB-2 and EGFR expression in ovarian tumors. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | KOREAN SOCIETY PATHOLOGISTS | - |
dc.title | 난소의 경계성 및 악성 표면상피종양에서 c-erbB-2, EGFR, p53 발현 및 Ki-67 지수에 관한 연구 | - |
dc.title.alternative | The expression of c-erbB-2, EGFP, p53 and Ki-67 in ovarian borderline tumors and carcinomas of the ovary | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 민경환 | - |
dc.identifier.wosid | 000258572100002 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PATHOLOGY, v.41, no.5, pp.296 - 306 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.volume | 41 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 296 | - |
dc.citation.endPage | 306 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | METASTATIC BREAST-CANCER | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | HER-2/NEU | - |
dc.subject.keywordPlus | AMPLIFICATION | - |
dc.subject.keywordPlus | IMMUNOHISTOCHEMISTRY | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | ONCOGENE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | ovarian neoplasms | - |
dc.subject.keywordAuthor | receptor | - |
dc.subject.keywordAuthor | erbB-2 | - |
dc.subject.keywordAuthor | epidermal growth factor | - |
dc.subject.keywordAuthor | p53 antigen | - |
dc.subject.keywordAuthor | Ki-67 antigen | - |
dc.identifier.url | https://www.jpatholtm.org/upload/pdf/kjp-41-5-296.pdf | - |
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