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Human muscle-derived cell injection in a rat model of stress urinary incontinence
- Authors
- Kim, Yong Tae; Kim, Dae Kyung; Jankowski, Ron J.; Pruchnic, Ryan; Usiene, Irmute; de Miguel, Fernando; Chancellor, Michael B.
- Issue Date
- Sep-2007
- Publisher
- JOHN WILEY & SONS INC
- Keywords
- incontinence; muscle; skeletal muscle; stem cell; stress urinary incontinence; urethra
- Citation
- MUSCLE & NERVE, v.36, no.3, pp.391 - 393
- Indexed
- SCIE
SCOPUS
- Journal Title
- MUSCLE & NERVE
- Volume
- 36
- Number
- 3
- Start Page
- 391
- End Page
- 393
- ISSN
- 0148-639X
- Abstract
- We investigated the use of human muscle-derived cells (hMDCs) for the treatment of stress urinary incontinence (SUI) in a nude rat model. hMDCs were isolated from adult skeletal muscle. Three groups of six animals consisting of controls, animals undergoing sciatic nerve transection (SNT) with periurethral sham-injection, and SNT with hMDCs (1 x 10(6) cells/20 mu l saline) were utilized. Leak point pressure (LPP) was measured 4 weeks following injection. Bilateral SNT resulted in a significantly lower LPP that was significantly higher following hMDCs than sham injection. The results demonstrate the efficacy of human muscle cell therapy alone in improving physiologic outcomes in an animal model of SUI.
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Collections - 서울 의과대학 > 서울 비뇨의학교실 > 1. Journal Articles
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Related Researcher
- Kim, Yong Tae
- COLLEGE OF MEDICINE (DEPARTMENT OF UROLOGY)