한국인에서 담석증과 인슐린 및 인슐린 저항성과의 관계
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김정미 | - |
dc.contributor.author | 이항락 | - |
dc.contributor.author | 문원 | - |
dc.contributor.author | 고동희 | - |
dc.contributor.author | 이오영 | - |
dc.contributor.author | 윤병철 | - |
dc.contributor.author | 최호순 | - |
dc.contributor.author | 함준수 | - |
dc.contributor.author | 이민호 | - |
dc.contributor.author | 이동후 | - |
dc.contributor.author | 안유현 | - |
dc.date.accessioned | 2022-12-21T07:07:46Z | - |
dc.date.available | 2022-12-21T07:07:46Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2007-07 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179856 | - |
dc.description.abstract | BACKGROUND/AIMS: Diabetes is one of the risk factors of gallstone diseases. Many studies found a positive association between insulin and gallstones in individuals with diabetes. However, this association is unclear in non-diabetes. So we conducted a case-control study for the evaluation of the association between gallstone diseases and fasting serum insulin level, insulin resistance in non-diabetic Korean general population. METHODS: This study was a prospective case-control study on 118 Korean subjects which included clinical examination, abdominal ultrasound, and blood chemistries. Serum fasting insulin level were determined by radioimmunoassay and concentrations of cholesterol, glucose, and triglycerides by standard enzymatic colorimetric methods. Insulin resistance was determined by the homeostasis model assessment (HOMA-IR). Body mass index (BMI), percentage of body fat, and waist hip ratio were also measured. RESULTS: We studied 118 subjects with no clinical evidence of diabetes mellitus and serum glucose <126 mg/dL. Compared with controls (n=89), cases (n=29) had higher levels of serum insulin, glucose, triglyceride levels, and BMI. In t-test and chi-square test for variables, the association between gallstone disease and serum insulin, HOMA-IR index, and BMI were statistically significant (p<0.05). In multiple logistic regression analysis, gallstone disease risk increased with the level of serum insulin (p=0.024, odds ratio=1.376) and HOMA-IR index (p=0.013, odds ratio=2.006). CONCLUSIONS: We suggest that hyperinsulinemia and insulin resistance could be associated with gallstone formation in individuals without clinical diagnosis of diabetes mellitus and with normal serum glucose level. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한소화기학회 | - |
dc.title | 한국인에서 담석증과 인슐린 및 인슐린 저항성과의 관계 | - |
dc.title.alternative | Association between Insulin, Insulin Resistance, and Gallstone Disease in Korean General Population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 이항락 | - |
dc.contributor.affiliatedAuthor | 이오영 | - |
dc.contributor.affiliatedAuthor | 윤병철 | - |
dc.contributor.affiliatedAuthor | 최호순 | - |
dc.identifier.scopusid | 2-s2.0-58149094887 | - |
dc.identifier.bibliographicCitation | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, v.50, no.3, pp.183 - 187 | - |
dc.relation.isPartOf | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi | - |
dc.citation.title | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi | - |
dc.citation.volume | 50 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 183 | - |
dc.citation.endPage | 187 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001258169 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | insulin | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | blood | - |
dc.subject.keywordPlus | body mass | - |
dc.subject.keywordPlus | case control study | - |
dc.subject.keywordPlus | comparative study | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gallstone | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | hyperinsulinism | - |
dc.subject.keywordPlus | insulin resistance | - |
dc.subject.keywordPlus | Korea | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | middle aged | - |
dc.subject.keywordPlus | regression analysis | - |
dc.subject.keywordPlus | risk factor | - |
dc.subject.keywordPlus | Adult | - |
dc.subject.keywordPlus | Body Mass Index | - |
dc.subject.keywordPlus | Case-Control Studies | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Gallstones | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Hyperinsulinism | - |
dc.subject.keywordPlus | Insulin | - |
dc.subject.keywordPlus | Insulin Resistance | - |
dc.subject.keywordPlus | Korea | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Middle Aged | - |
dc.subject.keywordPlus | Regression Analysis | - |
dc.subject.keywordPlus | Risk Factors | - |
dc.subject.keywordAuthor | Gallstone diseases | - |
dc.subject.keywordAuthor | Insulin | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.identifier.url | https://www.kjg.or.kr/journal/view.html?uid=3841&vmd=Full | - |
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