Association of the 22510A/G chemokine (C-C motif) ligand 2 polymorphism with knee osteoarthritis in a Korean population
DC Field | Value | Language |
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dc.contributor.author | Park, Hae Jeong | - |
dc.contributor.author | Yoon, Seung Ho | - |
dc.contributor.author | Zheng, Longtai | - |
dc.contributor.author | Lee, Kyu Hoon | - |
dc.contributor.author | Kim, JW | - |
dc.contributor.author | Chung, Joo Ho | - |
dc.contributor.author | Lee, Yeon Ah | - |
dc.contributor.author | Hong, Seung Jae | - |
dc.date.accessioned | 2022-12-21T07:08:08Z | - |
dc.date.available | 2022-12-21T07:08:08Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2007-07 | - |
dc.identifier.issn | 0300-9742 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179858 | - |
dc.description.abstract | Objective: To investigate the possible association between polymorphisms [the -2510A/ G promoter polymorphism ( rs1024611) and the Cys35Cys coding polymorphism ( rs4586) in exon 2] of the chemokine (C - C motif) ligand 2 (CCL2) gene and knee osteoarthritis ( OA) in a Korean population. Methods: DNA was obtained from 153 Korean primary knee OA patients and 270 healthy controls. CCL2 genomic variants (-2510A/ G and Cys35Cys polymorphisms) were detected by polymerase chain reactionrestriction fragment length polymorphism (PCR- RFLP). In additional, the effect of 22510A/ G on CCL2 transcription was examined, using a luciferase reporter gene construct transfected into HMC-1 cells. Results: The 22510A/ G promoter polymorphism was associated with OA [genotype frequency, p=0.041; allele frequency, p=0.017, odds ratio (OR) =1.45, 95% confidence interval (CI) =1.07 - 1.96]. Significant association was observed between the G carrier of the 22510A/ G promoter polymorphism and primary knee OA patients (p=0.021, OR=2.25, 95% CI=1.12 - 4.52). The G carrier of the 22510A/ G promoter polymorphism was also associated with both clinically subtyped OA patients ( OA patients with functionally poor index and radiographically severe OA patients). However, no significant difference was found in the Cys35Cys polymorphism. Haplotype frequency analysis revealed a significant difference (chi(2) =8.98, p=0.030). The CCL2 serum level of subjects with the G carrier ( 290.0 +/- 87.5 pg/ mL) of the 22510A/ G promoter polymorphism was statistically higher than that of subjects with the non-G carrier (161.5 +/- 48.3 pg/ mL). The luciferase activity was significantly greater from interleukin (IL)-1 beta- induced cells transfected with constructs containing G at position-2510. Conclusions: The G carrier of the 22510A/ G promoter polymorphism was found to be associated with primary knee OA, and could be a susceptibility factor in the development of primary knee OA in the Korean population. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Association of the 22510A/G chemokine (C-C motif) ligand 2 polymorphism with knee osteoarthritis in a Korean population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kyu Hoon | - |
dc.identifier.doi | 10.1080/03009740701288165 | - |
dc.identifier.scopusid | 2-s2.0-34548321260 | - |
dc.identifier.wosid | 000249013800008 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, v.36, no.4, pp.299 - 306 | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | - |
dc.citation.title | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 299 | - |
dc.citation.endPage | 306 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | - |
dc.subject.keywordPlus | MCP-1 PROMOTER-2518 POLYMORPHISM | - |
dc.subject.keywordPlus | INTERLEUKIN-1 GENE-CLUSTER | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ALLELE | - |
dc.subject.keywordPlus | ALPHA | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/03009740701288165 | - |
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