Helicobacter pylori 제균 후 위축위염과 장상피화생의 변화Histological changes of gastric atrophy and intestinal metaplasia after Helicobacter pylori eradication
- Other Titles
- Histological changes of gastric atrophy and intestinal metaplasia after Helicobacter pylori eradication
- Authors
- 이용구; 전용철; 구태연; 조현석; 변태준; 김태엽; 이항락; 은창수; 이오영; 한동수; Sohn, J.H.; Yoon, B.C.
- Issue Date
- May-2007
- Publisher
- 대한소화기학회
- Keywords
- Helicobacter pylori; Eradication; Atrophy; Intestinal metaplasia
- Citation
- The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, v.50, no.5, pp.299 - 305
- Indexed
- SCOPUS
KCI
- Journal Title
- The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
- Volume
- 50
- Number
- 5
- Start Page
- 299
- End Page
- 305
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/180141
- ISSN
- 1598-9992
- Abstract
- BACKGROUND/AIMS: Long-term Helicobater pylori infection results in atrophic gastritis and intestinal metaplasia, and increases the risk of gastric cancer. However, it is still controversial that eradication of H. pylori improves atrophy or metaplasia. Therefore, we investigated histological changes after the H. pylori eradication in patients with atrophy or metaplasia. METHODS: One hundred seven patients who received successful eradication of H. pylori infection in Hanyang University, Guri Hospital from March 2001 to April 2006, were enrolled. Antral biopsy was taken before the eradication to confirm the H. pylori infection and grade of atrophy or metaplasia by updated Sydney System. After a certain period of time, antral biopsy was repeatedly taken to confirm the eradication and investigate histological changes of atrophy or metaplasia. RESULTS: Mean age of the patients was 55.3+/-11.3, and average follow-up period was 28.7+/-13.9 months. Endoscopic diagnosis included gastric ulcer, duodenal ulcer, non-ulcer antral gastritis. Atrophy was observed in 41 of 91 and their average score was 0.73+/-0.92. After the eradication of H. pylori, atrophy was improved (0.38+/-0.70, p=0.025). However, metaplasia which was observed in 49 of 107, did not significantly improve during the follow-up period. Newly developed atrophy (7 of 38) or metaplasia (18 of 49) was observed in patients who without atrophy or metaplasia initially. Their average scores were slightly lower than those of cases with pre-existing atrophy or metaplasia without statistical significance. CONCLUSIONS: After the eradication of H. pylori infection, atrophic gastritis may be improved, but change of intestinal metaplasia is milder and may take longer duration for improvement.
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